🧬 Catalyst Radarupdated 2026-10-02 05:42 ET · 57 live trials · 5 data due · 34 beyond window
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Data due — completion passed, topline pending
RGNXdata due · 17d
AFFINITY DUCHENNE: RGX-202 Gene Therapy in Participants With Duchenne Muscular Dystrophy (
completed 2026-09 · n=65
BNTXdata due · 51d
A Study of DB-1303/BNT323 vs Investigator's Choice Chemotherapy in HER2-Low, Hormone Recep
completed 2026-08-12 · n=541 · LEAPS ✓
MRNAdata due · 70d
A Study to Investigate the Immunogenicity and Safety of mRNA-1345 Vaccine Targeting Respir
completed 2026-07-24 · n=1153 · LEAPS ✓
RNAdata due · 71d
Global Study of Del-desiran for the Treatment of DM1
completed 2026-07-23 · n=159 · LEAPS ✓
IONSdata due · 107d
FUSION: A Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of
completed 2026-06-17 · n=89 · LEAPS ✓
Last 14 days
2026-10-02
Left window
IOVA E7 T-cell Receptor (TCR) -T Cell Induction Therapy for Locoregionally Advanced HPV-associa — 2026-10-01 NCT05639972
Left window
BNTX A Study to Evaluate of PM8002 Combined With PM1009 in Patients With First-line HCC — 2026-10 NCT06584071
2026-10-01
Left window
QURE Safety, Tolerability, and Exploratory Efficacy Study of Intrathecally Administered Gene Th — 2026-09-30 NCT06100276
2026-09-30
Status
IONS REVEAL: A Phase 3 Study of Obudanersen (ION582) in Angelman Syndrome — recruiting → active not recruiting NCT06914609
2026-09-29
Status
IONS CHAMPION: A Study to Evaluate the Efficacy and Safety of Obudanersen (ION582) in Children — not yet recruiting → recruiting NCT07782827
2026-09-25
Slipped
BNTX A Study of DB-1303/BNT323 vs Investigator's Choice Chemotherapy in HER2-Low, Hormone Recep — 2026-06 → 2026-08-12 NCT06018337
Firmed
BNTX A Study of DB-1303/BNT323 vs Investigator's Choice Chemotherapy in HER2-Low, Hormone Recep — data inside a quarter NCT06018337
2026-09-23
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MRNA Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of mRNA-1403 and mRNA-140 — 2026-09-22 NCT05992935
2026-09-20
Pulled in
ALNY Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Establ — 2030-09-30 → 2030-09-23 NCT07181109
Status
MRNA A Study of Intismeran Autogene (V940) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pem — recruiting → active not recruiting NCT06077760
Next 30 days
3d
MRNA P2 est A Study of an Epstein-Barr Virus (EBV) Candidate Vaccine, mRNA-1189, in 10- to 30-Year-Old · 2026-10-05 · n=867 NCT05164094
~13d
RGNX P3 est Pivotal 2 Study of RGX-314 Gene Therapy in Participants With nAMD · 2026-10 · n=735 NCT05407636
13d
SLDB P2 est Microdystrophin Gene Transfer Study in Adolescents and Children With DMD · 2026-10-15 · n=12 NCT03368742
28d
BNTX P2 est A Study of PM8002 Plus Nab-paclitaxel as First Line Therapy for TNBC · 2026-10-30 · n=42 NCT05918133
29d
SRPT P3 est A Study to Compare Safety and Efficacy of High Doses of Eteplirsen in Participants With Du · 2026-10-31 · n=160 NCT03992430

Registry dates slip constantly — the feed is the signal; confirm against company guidance before positioning.

All names — sorted by next catalyst; tap a card for the full story
IONSIonis Pharmaceuticals · RNA
data due · 107d
data due · 2026-06-17
8 in window · 6 beyond
LEAPS ✓ to 2029-01-19
In the 12-month window
data due · 107d
P3 firm FUSION: A Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of
NCT04768972 · n=89 · Amyotrophic Lateral Sclerosis · Ionis Pharmaceuticals, Inc.
~74d
P3 est A Study to Assess the Long-Term Safety and Efficacy of Donidalorsen in the Prophylactic Tr
NCT05392114 · n=154 · Hereditary Angioedema · Ionis Pharmaceuticals, Inc.
~164d
P3 est CORE-OLE: A Study of Olezarsen (ISIS 678354) Administered Subcutaneously to Participants W
NCT05681351 · n=885 · Severe Hypertriglyceridemia · Ionis Pharmaceuticals, Inc.
~195d
P2 est PrProfile: A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynami
NCT06153966 · n=85 · Prion Disease · Ionis Pharmaceuticals, Inc.
~256d
P3 est A Study of Olezarsen (Formerly Known as AKCEA-APOCIII-LRX) Administered to Adults With Fam
NCT05185843 · n=24 · Familial Chylomicronemia Syndrome · Ionis Pharmaceuticals, Inc.
~317d
P3 est REVEAL: A Phase 3 Study of Obudanersen (ION582) in Angelman Syndrome
NCT06914609 · n=156 · Angelman Syndrome · Ionis Pharmaceuticals, Inc.
~348d
P2 est A Study to Assess the Safety, Tolerability and Efficacy of ION775
NCT07604974 · n=72 · Hypertriglyceridemia; Severe Hypertriglyceridemia · Ionis Pharmaceuticals, Inc.
~348d
P2 est ATTUNE: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynami
NCT06430385 · n=48 · Methyl CpG Binding Protein 2 (MECP2) Duplication Syndrome · Ionis Pharmaceuticals, Inc.
Beyond the window — timing from guidance, not registry (interims strike early)
~501d
P3 est A Study of Olezarsen (Formerly Known as AKCEA-APOCIII-LRx) in Participants With Familial C
NCT05130450 · n=60 · Familial Chylomicronemia Syndrome · Ionis Pharmaceuticals, Inc.
~591d
P3 est CHAMPION: A Study to Evaluate the Efficacy and Safety of Obudanersen (ION582) in Children
NCT07782827 · n=30 · Angelman Syndrome · Ionis Pharmaceuticals, Inc.
~987d
P3 est Donidalorsen Treatment in Children With Hereditary Angioedema
NCT07298447 · n=20 · Hereditary Angioedema (HAE) · Ionis Pharmaceuticals, Inc.
~1048d
P3 est An Extension Study to Assess Long-Term Safety of Eplontersen in Adults With Transthyretin-
NCT05667493 · n=1400 · Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM) · Ionis Pharmaceuticals, Inc. w/ AstraZeneca
~1048d
P3 est A Study to Assess the Long-Term Safety and Efficacy of Eplontersen (Formerly Known as ION-
NCT05071300 · n=151 · Hereditary Transthyretin-Mediated Amyloid Polyneuropathy · Ionis Pharmaceuticals, Inc.
~1413d
P3 est A Study of Olezarsen for the Treatment of Familial Chylomicronemia Syndrome (FCS) in Pedia
NCT07727538 · n=12 · Familial Chylomicronemia Syndrome · Ionis Pharmaceuticals, Inc.
Options
expirations 8furthest 2029-01-19LEAPS ✓
RNAAvidity Biosciences · RNA
data due · 71d
data due · 2026-07-23
2 in window · 3 beyond
LEAPS ✓ to 2028-01-21
In the 12-month window
data due · 71d
P3 firm Global Study of Del-desiran for the Treatment of DM1
NCT06411288 · n=159 · DM1; Myotonic Dystrophy; Myotonic Dystrophy 1 · Avidity Biosciences, Inc.
210d
P2 est Ph2 Open-label Study of AOC 1044 in Duchenne Muscular Dystrophy Participants With Mutation
NCT06244082 · n=39 · DMD; Duchenne Muscular Dystrophy; Duchenne · Avidity Biosciences, Inc.
Beyond the window — timing from guidance, not registry (interims strike early)
~591d
P3 est A Study to Evaluate Del-brax (Also Referred to as AOC 1020) in Participants With FSHD
NCT07038200 · n=200 · Facioscapulohumeral Muscular Dystrophy; FSHD; FSHD - Facioscapulohumeral Muscular Dystrophy · Avidity Biosciences, Inc.
~956d
P3 est A Phase 3 Study to Evaluate the Safety and Efficacy of AOC 1044 (Also Referred to as Delpa
NCT07587242 · n=70 · Muscular Dystrophies; Muscular Dystrophies (Duchenne, Becker, Myotonic Dystrophy); Muscular Disorders, Atrophic · Avidity Biosciences, Inc.
~1474d
P3 est Global Open-Label Extension Study of Del-desiran for the Treatment of DM1
NCT07008469 · n=199 · Myotonic Dystrophy Type 1; DM1; Myotonic Dystrophy · Avidity Biosciences, Inc.
Options
expirations 3furthest 2028-01-21LEAPS ✓
MRNAModerna · mRNA
data due · 70d
data due · 2026-07-24
8 in window · 2 beyond
LEAPS ✓ to 2029-01-19
In the 12-month window
data due · 70d
P3 firm A Study to Investigate the Immunogenicity and Safety of mRNA-1345 Vaccine Targeting Respir
NCT06067230 · n=1153 · Respiratory Syncytial Virus · ModernaTX, Inc.
3d
P2 est A Study of an Epstein-Barr Virus (EBV) Candidate Vaccine, mRNA-1189, in 10- to 30-Year-Old
NCT05164094 · n=867 · Epstein-Barr Virus Infection · ModernaTX, Inc.
59d
P2 est A Study of mRNA-3745 in Adult and Pediatric Participants With Glycogen Storage Disease Typ
NCT05095727 · n=15 · Glycogen Storage Disease · ModernaTX, Inc.
118d
P3 est A Study of mRNA-1018-H5 Pandemic Influenza Vaccine in Healthy Adults
NCT07496450 · n=4050 · Influenza · ModernaTX, Inc.
136d
P3 est A Study to Investigate the Safety and Efficacy of mRNA-1403 in Participants ≥18 Years of A
NCT06592794 · n=37864 · Acute Gastroenteritis; Norovirus Acute Gastroenteritis · ModernaTX, Inc.
155d
P2 est A Study to Evaluate the Efficacy, Safety, and Immunogenicity of mRNA-1647 Cytomegalovirus
NCT05683457 · n=84 · Cytomegalovirus Infection · ModernaTX, Inc.
203d
P2 est A Clinical Study of Intismeran Autogene (V940) Treatment and Pembrolizumab in People With
NCT06305767 · n=230 · Bladder Cancer · Merck Sharp & Dohme LLC w/ ModernaTX, Inc.
333d
P2 est Open-Label Study of mRNA-3927 in Participants With Propionic Acidemia
NCT04159103 · n=77 · Propionic Acidemia · ModernaTX, Inc.
Beyond the window — timing from guidance, not registry (interims strike early)
1120d
P3 est A Clinical Study of Intismeran Autogene (V940) Plus Pembrolizumab in People With High-Risk
NCT05933577 · n=1089 · Melanoma · Merck Sharp & Dohme LLC w/ ModernaTX, Inc.
1362d
P3 est A Study of Intismeran Autogene (V940) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pem
NCT06077760 · n=868 · Non-small Cell Lung Cancer · Merck Sharp & Dohme LLC w/ ModernaTX, Inc.
Options
expirations 18furthest 2029-01-19LEAPS ✓
Journal mentions
2026-08-19 — 2026-08-19 — Radar built and deployed
“Therapeutics (RNAC)** — mRNA CAR-T for myasthenia gravis, pivotal window” open →
BNTXBioNTech · mRNA
data due · 51d
data due · 2026-08-12
12 in window · 9 beyond · 4 routine
LEAPS ✓ to 2029-01-19
In the 12-month window
data due · 51d
P3 firm A Study of DB-1303/BNT323 vs Investigator's Choice Chemotherapy in HER2-Low, Hormone Recep
NCT06018337 · n=541 · Metastatic Breast Cancer · DualityBio Inc. w/ BioNTech SE
28d
P2 est A Study of PM8002 Plus Nab-paclitaxel as First Line Therapy for TNBC
NCT05918133 · n=42 · TNBC · Biotheus Inc.
~44d
P2 est A Phase II Clinical Trial Comparing the Efficacy of RO7198457 Versus Watchful Waiting in P
NCT04486378 · n=327 · Colorectal Cancer Stage II; Colorectal Cancer Stage III · BioNTech SE w/ Genentech, Inc.
91d
P2 est A Study of PM8002 in Combination With Chemotherapy in Patients With NEN
NCT05879055 · n=31 · Neuroendocrine Neoplasm · Biotheus Inc.
115d
P3 est PM8002 in Combination With Paclitaxel Compared With Chemotherapy as Second-line Treatment
NCT06616532 · n=404 · SCLC · Biotheus Inc.
~225d
P2 est PM8002 (BNT327) in Combination With Chemotherapy in Patients With Metastatic Colorectal Ca
NCT07133750 · n=100 · CRC (Colorectal Cancer) · Biotheus Inc. w/ BioNTech SE
~256d
P2 est A Randomized Clinical Trial Investigating the Safety, Reactogenicity, and Immunogenicity A
NCT07379580 · n=310 · Mpox (Monkeypox); Smallpox; Orthopoxvirus Infection · BioNTech SE w/ Coalition for Epidemic Preparedness Innovations
~256d
P2 est Safety, Preliminary Effectiveness of BNT327, an Investigational Therapy for Patients With
NCT06449209 · n=110 · Extensive-stage Small-cell Lung Cancer; Small-cell Lung Cancer · BioNTech SE
~286d
P3 est PM8002 or Placebo Plus Nab-Paclitaxel as First-line Treatment in Inoperable Locally Advanc
NCT06419621 · n=392 · Triple Negative Breast Cancer(TNBC) · Biotheus Inc.
~317d
P2 est A Phase 1/2a Study of DB-1303/BNT323 in Advanced/Metastatic Solid Tumors
NCT05150691 · n=796 · HER2-positive Advanced Solid Tumor · DualityBio Inc. w/ BioNTech SE
315d
P2 est First-in-human Study of DB-1305/BNT325 for Advanced/Metastatic Solid Tumors
NCT05438329 · n=1123 · Advanced Solid Tumor · DualityBio Inc. w/ BioNTech SE
333d
P3 est ONC-392 Versus Docetaxel in Metastatic NSCLC That Progressed on PD-1/PD-L1 Inhibitors
NCT05671510 · n=630 · Non Small Cell Lung Cancer · OncoC4, Inc. w/ BioNTech SE
Beyond the window — timing from guidance, not registry (interims strike early)
~530d
P3 est A Clinical Study of the Anti-cancer Effects of an Investigational Therapy or Chemotherapy
NCT06340568 · n=480 · Endometrial Cancer · BioNTech SE w/ DualityBio Inc.; BioNTech (Shanghai) Pharmaceuticals Co., Ltd.
~683d
P3 est A Clinical Trial Investigating the Safety, Tolerability, and Therapeutic Effects of BNT113
NCT04534205 · n=358 · Unresectable Head and Neck Squamous Cell Carcinoma; Metastatic Head and Neck Cancer; Recurrent Head and Neck Cancer · BioNTech SE
~805d
P3 est Safety and Efficacy of BNT327, an Investigational Therapy in Combination With Chemotherapy
NCT06712355 · n=621 · Extensive-stage Small-cell Lung Cancer · BioNTech SE w/ Bristol-Myers Squibb
~836d
P3 est Safety, Efficacy, and Pharmacokinetics of BNT327 in Combination With Chemotherapy and Othe
NCT06712316 · n=1580 · Non-small Cell Lung Cancer · BioNTech SE w/ Bristol-Myers Squibb
~1170d
P3 est ROSETTA Breast-01: The Effects and Safety of Pumitamig in Patients With Triple-Negative Br
NCT07173751 · n=558 · Breast Neoplasms · BioNTech SE w/ Bristol-Myers Squibb
1219d
P3 est A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy
NCT07221357 · n=990 · Untreated, Unresectable, or Metastatic Colorectal Cancer · Bristol-Myers Squibb w/ BioNTech SE
1447d
P3 est A Study to Evaluate Pumitamig Versus Durvalumab Following Concurrent Chemoradiation Therap
NCT07361497 · n=850 · Non-small Cell Lung Cancer (NSCLC) · Bristol-Myers Squibb w/ BioNTech SE
1498d
P3 est A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy
NCT07221149 · n=690 · Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma · Bristol-Myers Squibb w/ BioNTech SE
~1597d
P3 est A Phase III Trial of BNT324 Versus Docetaxel in Metastatic Castration-resistant Prostate C
NCT07365995 · n=736 · Metastatic Castration-resistant Prostate Cancer · BioNTech SE w/ BioNTech (Shanghai) Pharmaceuticals Co., Ltd.; DualityBio Inc.
4 routine trials (strain updates, extensions, tracers)
data due · 84d
P3 firm A Study to Learn About Variant-Adapted COVID-19 RNA Vaccine Candidate(s) in Healthy Childr
NCT05543616 · n=4338 · SARS-CoV-2 Virus; Severe Acute Respiratory Syndrome Coronavirus 2; COVID-19 · BioNTech SE w/ Pfizer
data due · 70d
P3 firm A Study to Learn About BNT162b2 (LP.8.1)-Adapted Vaccine Against SARS-CoV-2 in Children 5
NCT07222384 · n=344 · COVID-19; SARS-COV-2 Infection · BioNTech SE w/ Pfizer
data due · 63d
P3 est A Study to Learn About a COVID-19 Vaccine in Healthy Adults 50 Through 64 Years of Age
NCT07300839 · n=5240 · COVID-19; SARS-COV-2 Infection · BioNTech SE w/ Pfizer
201d
P3 est A Study of COVID-19 Vaccine(s) in Children and Adults
NCT07798648 · n=700 · COVID-19 Vaccines · BioNTech SE w/ Pfizer
Options
expirations 11furthest 2029-01-19LEAPS ✓
RGNXREGENXBIO · AAV
data due · 17d
data due · 2026-09
3 in window · 1 beyond
options to 2027-04-16 · no LEAPS
In the 12-month window
data due · 17d
P3 est AFFINITY DUCHENNE: RGX-202 Gene Therapy in Participants With Duchenne Muscular Dystrophy (
NCT05693142 · n=65 · Duchenne Muscular Dystrophy · REGENXBIO Inc.
~13d
P3 est Pivotal 2 Study of RGX-314 Gene Therapy in Participants With nAMD
NCT05407636 · n=735 · AMD; nAMD; Wet Age-related Macular Degeneration · AbbVie w/ REGENXBIO Inc.
~74d
P3 est Pivotal 1 Study of ABBV-RGX-314 (Also Known as RGX-314) Gene Therapy Administered Via Subr
NCT04704921 · n=671 · AMD; nAMD; Wet Age-related Macular Degeneration · AbbVie w/ REGENXBIO Inc.
Beyond the window — timing from guidance, not registry (interims strike early)
576d
P3 est RGX-121-3102 Gene Therapy in Participants With MPS II (Hunter Syndrome)
NCT07236606 · n=2 · MPS II; Hunter Syndrome (MPS II) · REGENXBIO Inc.
Options
expirations 4furthest 2027-04-16LEAPS no
Journal mentions
2026-08-19 — 2026-08-19 — Radar built and deployed
“names. Nearest: REGENXBIO's Duchenne gene therapy (September 2026), the” open →
SLDBSolid Biosciences · AAV
~13d
P2 · 2026-10-15
2 in window · 1 beyond
options to 2027-03-19 · no LEAPS
In the 12-month window
13d
P2 est Microdystrophin Gene Transfer Study in Adolescents and Children With DMD
NCT03368742 · n=12 · Duchenne Muscular Dystrophy · Solid Biosciences Inc.
216d
P2 est A Study of SGT-003 Gene Therapy in Duchenne Muscular Dystrophy (INSPIRE DUCHENNE)
NCT06138639 · n=60 · Duchenne Muscular Dystrophy · Solid Biosciences Inc.
Beyond the window — timing from guidance, not registry (interims strike early)
~836d
P3 est A Study of SGT-003 Gene Therapy in Ambulant Males With Duchenne Muscular Dystrophy (IMPACT
NCT07160634 · n=80 · Duchenne Muscular Dystrophy · Solid Biosciences Inc.
Options
expirations 5furthest 2027-03-19LEAPS no
SRPTSarepta Therapeutics · AAV
~29d
P3 · 2026-10-31
3 in window
LEAPS ✓ to 2029-01-19
In the 12-month window
29d
P3 est A Study to Compare Safety and Efficacy of High Doses of Eteplirsen in Participants With Du
NCT03992430 · n=160 · Muscular Dystrophy, Duchenne · Sarepta Therapeutics, Inc.
90d
P2 est Study of SRP-1003 in Participants With Type 1 Myotonic Dystrophy
NCT06138743 · n=78 · Myotonic Dystrophy 1 · Sarepta Therapeutics, Inc.
241d
P3 est A Gene Transfer Therapy Study to Evaluate the Safety and Efficacy of Delandistrogene Moxep
NCT05881408 · n=148 · Duchenne Muscular Dystrophy · Sarepta Therapeutics, Inc. w/ Hoffmann-La Roche
Options
expirations 16furthest 2029-01-19LEAPS ✓
ALNYAlnylam Pharmaceuticals · RNA
~44d
PDUFA · 2026-11-15
5 in window · 4 beyond
LEAPS ✓ to 2029-01-19
PDUFA · 2026-11-15 · guided
Cemdisiran, partnered with Regeneron, has an FDA target action date in November 2026 for generalized myasthenia gravis under priority review. source
In the 12-month window
207d
P2 est A Study to Evaluate ALN-2232 in Participants With Obesity
NCT07463846 · n=156 · Obesity · Alnylam Pharmaceuticals
238d
P2 est A Study to Evaluate ALN-4324 on Insulin Sensitivity in Adults With Type 2 Diabetes Mellitu
NCT07465224 · n=24 · Type 2 Diabetes Mellitus (T2DM) · Alnylam Pharmaceuticals
271d
P2 est HMBeacon: A Phase 2 Study to Evaluate ALN-6400 in Adult and Adolescent Female Patients Wit
NCT07575308 · n=24 · Von Willebrand Disease (VWD); Heavy Menstrual Bleeding (HMB) · Alnylam Pharmaceuticals
311d
P2 est A Phase 2 Trial of ALN-APP in Patients With Cerebral Amyloid Angiopathy
NCT06393712 · n=210 · Cerebral Amyloid Angiopathy · Alnylam Pharmaceuticals
333d
P2 est A Study to Evaluate ALN-4324 in Overweight to Obese Healthy Volunteers and in Overweight t
NCT06845202 · n=105 · Obese or Overweight Healthy Volunteers; Type 2 Diabetes Mellitus (T2DM) · Alnylam Pharmaceuticals
Beyond the window — timing from guidance, not registry (interims strike early)
451d
P3 est TRITON-PN: A Study to Evaluate the Efficacy and Safety of Nucresiran in Patients With Here
NCT07223203 · n=125 · Hereditary Transthyretin-Mediated Amyloidosis With Polyneuropathy; hATTR-PN · Alnylam Pharmaceuticals
546d
P3 est A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopa
NCT06679946 · n=700 · Transthyretin Amyloidosis (ATTR) With Cardiomyopathy · Alnylam Pharmaceuticals
1334d
P3 est TRITON-CM: A Study to Evaluate Nucresiran in Patients With Transthyretin Amyloidosis With
NCT07052903 · n=1750 · Transthyretin Amyloidosis With Cardiomyopathy · Alnylam Pharmaceuticals
1452d
P3 est Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Establ
NCT07181109 · n=11000 · High Risk Cardiovascular Disease; Hypertension; High Cardiovascular Risk · Alnylam Pharmaceuticals w/ Hoffmann-La Roche
Options
expirations 8furthest 2029-01-19LEAPS ✓
QUREuniQure · AAV
~59d
P2 · 2026-11-30
1 in window
LEAPS ✓ to 2029-01-19
Filing · 2026-09-30 · guided
AMT-130 for Huntington's disease — BLA submission guided for Q3 2026 after uniQure and the FDA aligned in June 2026 on an accelerated-approval path; an approval decision would follow roughly mid-2027. source
In the 12-month window
59d
P2 est AMT-260 Gene Therapy Study in Adults With Unilateral Refractory Mesial Temporal Lobe Epile
NCT06063850 · n=12 · Mesial Temporal Lobe Epilepsy · UniQure Biopharma B.V.
Options
expirations 7furthest 2029-01-19LEAPS ✓
Journal mentions
2026-08-19 — 2026-08-19 — Radar built and deployed
“2027 ATTR timeline as soft. uniQure got FDA alignment in June 2026 for an” open →
RNACCartesian Therapeutics · Cell
~60d
P2 · 2026-12-01
2 in window
options to 2027-05-21 · no LEAPS
In the 12-month window
60d
P2 est Descartes-08 for Patients With Systemic Lupus Erythematosus
NCT06038474 · n=6 · Systemic Lupus Erythematosus (SLE) · Cartesian Therapeutics
89d
P3 est Investigating an mRNA CAR T-cell Therapy, Known as Descartes-08, as a Potential Approach t
NCT06799247 · n=128 · Myasthaenia Gravis · Cartesian Therapeutics
Options
expirations 4furthest 2027-05-21LEAPS no
Journal mentions
2026-08-19 — 2026-08-19 — Radar built and deployed
“Therapeutics (RNAC)** — mRNA CAR-T for myasthenia gravis, pivotal window” open →
BEAMBeam Therapeutics · Editing
~74d
P2 · 2026-12
1 in window
LEAPS ✓ to 2028-01-21
In the 12-month window
~74d
P2 est A Study Evaluating the Safety and Efficacy of BEAM-201 in Relapsed/Refractory T-Cell Acute
NCT05885464 · n=5 · Lymphoblastic Lymphoma; T-Cell Lymphoblastic Leukemia/Lymphoma; Lymphoblastic Leukemia · Beam Therapeutics Inc.
Options
expirations 6furthest 2028-01-21LEAPS ✓
LXEOLexeo Therapeutics · AAV
~74d
P2 · 2026-12
1 in window
options to 2027-05-21 · no LEAPS
In the 12-month window
~74d
P2 est Gene Therapy for ACM Due to a PKP2 Pathogenic Variant
NCT06109181 · n=10 · Arrhythmogenic Cardiomyopathy; PKP2-ACM; PKP2-ARVC · Lexeo Therapeutics
Options
expirations 4furthest 2027-05-21LEAPS no
NTLAIntellia Therapeutics · Editing
~74d
Filing · 2026-12-15
1 in window · 1 beyond
LEAPS ✓ to 2029-01-19
Filing · 2026-12-15 · guided
Lonvo-z (NTLA-2002) for hereditary angioedema — full BLA submission guided for the second half of 2026 after the HAELO pivotal trial succeeded in April 2026; Intellia plans a first-half-2027 launch, which would be the first approved in-vivo CRISPR therapy. source
In the 12-month window
~286d
P3 est A Phase 3 Study of NTLA-2001 in ATTRv-PN
NCT06672237 · n=60 · Neuromuscular Disease; Neuromuscular Diseases (NMD); Neurodegenerative Disease · Intellia Therapeutics w/ Regeneron Pharmaceuticals
Beyond the window — timing from guidance, not registry (interims strike early)
~439d
P3 est MAGNITUDE: A Phase 3 Study of NTLA-2001 in Participants With Transthyretin Amyloidosis Wit
NCT06128629 · n=1200 · Transthyretin Amyloidosis (ATTR) With Cardiomyopathy · Intellia Therapeutics w/ Regeneron Pharmaceuticals
Options
expirations 6furthest 2029-01-19LEAPS ✓
Journal mentions
2026-08-19 — 2026-08-19 — Radar built and deployed
“(ATTR) trials earlier in 2026 — the registry may lag on this; treat NTLA's” open →
NTRANatera · Dx
~74d
P3 · 2026-12
1 in window · 1 beyond
LEAPS ✓ to 2029-01-19
In the 12-month window
~74d
P3 est Evaluating Novel Therapies in ctDNA Positive GI Cancers
NCT05482516 · n=20 · Colon Adenocarcinoma; Rectal Adenocarcinoma; Gastric Adenocarcinoma · Georgetown University w/ Genentech, Inc.; Natera, Inc.
Beyond the window — timing from guidance, not registry (interims strike early)
890d
P3 est Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease
NCT05174169 · n=1912 · Stage III Colon Cancer · NRG Oncology w/ Natera, Inc.; National Cancer Institute (NCI)
Options
expirations 10furthest 2029-01-19LEAPS ✓
IOVAIovance Biotherapeutics · Cell
~91d
P2 · 2027-01-01
3 in window · 1 beyond
LEAPS ✓ to 2029-01-19
In the 12-month window
91d
P2 est E7 TCR-T Cell Immunotherapy for Human Papillomavirus (HPV) Associated Cancers
NCT05686226 · n=20 · Cervical Cancer; Throat Cancer; Oropharynx Cancer · Christian Hinrichs w/ National Cancer Institute (NCI); Iovance Biotherapeutics, Inc.
210d
P2 est LN-145 or LN-145-S1 in Treating Patients With Relapsed or Refractory Ovarian Cancer, Tripl
NCT03449108 · n=30 · Bone Sarcoma; Dedifferentiated Chondrosarcoma; Giant Cell Tumor of Bone · M.D. Anderson Cancer Center w/ Iovance Biotherapeutics, Inc.; National Cancer Institute (NCI)
~348d
P2 est A Study to Investigate the Efficacy and Safety of an Infusion of IOV-4001 in Adult Partici
NCT05361174 · n=53 · Unresectable Melanoma; Metastatic Melanoma; Stage III Non-small Cell Lung Cancer · Iovance Biotherapeutics, Inc.
Beyond the window — timing from guidance, not registry (interims strike early)
516d
P3 est Study to Investigate Lifileucel Regimen Plus Pembrolizumab Compared With Pembrolizumab Alo
NCT05727904 · n=670 · Metastatic Melanoma; Unresectable Melanoma; Melanoma · Iovance Biotherapeutics, Inc.
Options
expirations 13furthest 2029-01-19LEAPS ✓
TSHATaysha Gene Therapies · AAV
~161d
P2 · 2027-03-12
1 in window · 2 beyond
options to 2027-04-16 · no LEAPS
In the 12-month window
161d
P2 est First-in-Human Study of TSHA-101 Gene Therapy for Treatment of Infantile Onset GM2 Ganglio
NCT04798235 · n=3 · Infantile GM2 Gangliosidosis (Disorder) · Dr. Anupam Sehgal w/ Taysha Gene Therapies, Inc.; GlycoNet
Beyond the window — timing from guidance, not registry (interims strike early)
~1717d
P3 est Safety and Preliminary Efficacy of TSHA-102 Gene Therapy in Pediatric Females Aged >2 to <
NCT07480564 · n=4 · Rett Syndrome · Taysha Gene Therapies, Inc.
~1717d
P3 est A Phase 1/2/3 Study of TSHA-102 Gene Therapy in Females With Rett Syndrome (REVEAL Pivotal
NCT05606614 · n=17 · Rett Syndrome · Taysha Gene Therapies, Inc.
Options
expirations 5furthest 2027-04-16LEAPS no
STOKStoke Therapeutics · RNA
~164d
P3 · 2027-03
1 in window
LEAPS ✓ to 2027-12-17
In the 12-month window
~164d
P3 est A Double-blind Study Evaluating the Efficacy, Safety, and Tolerability of Zorevunersen in
NCT06872125 · n=170 · Dravet Syndrome · Stoke Therapeutics, Inc
Options
expirations 5furthest 2027-12-17LEAPS ✓
CRSPCRISPR Therapeutics · Editing
~247d
P3 · 2027-06-06
1 in window · 1 beyond
LEAPS ✓ to 2029-01-19
In the 12-month window
247d
P3 est Evaluation of Safety and Efficacy of CTX001 in Pediatric Participants With Severe Sickle C
NCT05329649 · n=13 · Sickle Cell Disease; Hydroxyurea Failure; Hydroxyurea Intolerance · Vertex Pharmaceuticals Incorporated w/ CRISPR Therapeutics
Beyond the window — timing from guidance, not registry (interims strike early)
408d
P3 est Evaluation of Safety and Efficacy of CTX001 in Pediatric Participants With Transfusion-Dep
NCT05356195 · n=16 · Beta-Thalassemia; Thalassemia; Genetic Diseases, Inborn · Vertex Pharmaceuticals Incorporated w/ CRISPR Therapeutics
Options
expirations 12furthest 2029-01-19LEAPS ✓
ARCTArcturus Therapeutics · mRNA
~256d
P2 · 2027-06
1 in window
options to 2027-03-19 · no LEAPS
In the 12-month window
~256d
P2 est Safety, Tolerability and Efficacy Study of ARCT-032 in People With Cystic Fibrosis
NCT06747858 · n=33 · Cystic Fibrosis; CFTR Gene Mutation · Arcturus Therapeutics, Inc.
Options
expirations 4furthest 2027-03-19LEAPS no
GHGuardant Health · Dx
event-driven · beyond window
1 beyond
LEAPS ✓ to 2029-01-19
Beyond the window — timing from guidance, not registry (interims strike early)
730d
P3 est Continuous or Intermittent Cetuximab Plus FOLFIRI as First-line Treatment in RAS/BRAF Wild
NCT07004413 · n=267 · Colorectal Cancer Metastatic · Charite University, Berlin, Germany w/ Guardant Health, Inc.; Merck KGaA, Darmstadt, Germany
Options
expirations 10furthest 2029-01-19LEAPS ✓
WGSGeneDx · Dx
event-driven · beyond window
1 beyond
LEAPS ✓ to 2029-01-19
Beyond the window — timing from guidance, not registry (interims strike early)
439d
P3 est Trial of Therapeutic Cancer Vaccine OSE2101 in Patients With Non-Small Cell Lung Cancer an
NCT06472245 · n=363 · Patients With Non-Small Cell Lung Cancer · OSE Immunotherapeutics w/ Exystat; GeneDx
Options
expirations 13furthest 2029-01-19LEAPS ✓
CRBUCaribou Biosciences · Editing
nothing in window
—
options to 2027-04-16 · no LEAPS
Options
expirations 4furthest 2027-04-16LEAPS no

No trials in the window and no known events — the jump risk here is early data, deals, or (for diagnostics) coverage decisions the registry cannot see.

EDITEditas Medicine · Editing
nothing in window
—
LEAPS ✓ to 2028-01-21
Options
expirations 6furthest 2028-01-21LEAPS ✓

No trials in the window and no known events — the jump risk here is early data, deals, or (for diagnostics) coverage decisions the registry cannot see.

ILMNIllumina · Dx
coverage & earnings driven
1 routine
LEAPS ✓ to 2028-01-21
1 routine trials (strain updates, extensions, tracers)
data due · 64d
P3 firm Open-Label Study of 18F-mFBG for Imaging Neuroblastoma
NCT04724369 · n=43 · Neuroblastoma · Innervate Radiopharmaceuticals LLC (Formerly: Illumina Radiopharmaceuticals LLC) w/ New Approaches to Neuroblastoma Therapy Consortium; Memorial Sloan Kettering Cancer Center
Options
expirations 7furthest 2028-01-21LEAPS ✓

No trials in the window and no known events — the jump risk here is early data, deals, or (for diagnostics) coverage decisions the registry cannot see.

MYGNMyriad Genetics · Dx
coverage & earnings driven
—
options to 2027-05-21 · no LEAPS
Options
expirations 4furthest 2027-05-21LEAPS no

No trials in the window and no known events — the jump risk here is early data, deals, or (for diagnostics) coverage decisions the registry cannot see.

PRMEPrime Medicine · Editing
nothing in window
—
LEAPS ✓ to 2029-01-19
Options
expirations 6furthest 2029-01-19LEAPS ✓

No trials in the window and no known events — the jump risk here is early data, deals, or (for diagnostics) coverage decisions the registry cannot see.

RCKTRocket Pharmaceuticals · AAV
nothing in window
—
options to 2027-04-16 · no LEAPS
Options
expirations 4furthest 2027-04-16LEAPS no

No trials in the window and no known events — the jump risk here is early data, deals, or (for diagnostics) coverage decisions the registry cannot see.

TEMTempus · Dx
coverage & earnings driven
—
LEAPS ✓ to 2029-01-19
Options
expirations 19furthest 2029-01-19LEAPS ✓

No trials in the window and no known events — the jump risk here is early data, deals, or (for diagnostics) coverage decisions the registry cannot see.

WVEWave Life Sciences · RNA
nothing in window
—
LEAPS ✓ to 2028-01-21
Options
expirations 7furthest 2028-01-21LEAPS ✓

No trials in the window and no known events — the jump risk here is early data, deals, or (for diagnostics) coverage decisions the registry cannot see.

Topline data typically lands one to four months after primary completion — "data due" rows are the hottest zone.

Due — completion passed
data due · 107d
IONS P3 firm FUSION: A Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of
NCT04768972 · n=89 · Amyotrophic Lateral Sclerosis · Ionis Pharmaceuticals, Inc. · LEAPS ✓
data due · 71d
RNA P3 firm Global Study of Del-desiran for the Treatment of DM1
NCT06411288 · n=159 · DM1; Myotonic Dystrophy; Myotonic Dystrophy 1 · Avidity Biosciences, Inc. · LEAPS ✓
data due · 70d
MRNA P3 firm A Study to Investigate the Immunogenicity and Safety of mRNA-1345 Vaccine Targeting Respir
NCT06067230 · n=1153 · Respiratory Syncytial Virus · ModernaTX, Inc. · LEAPS ✓
data due · 51d
BNTX P3 firm A Study of DB-1303/BNT323 vs Investigator's Choice Chemotherapy in HER2-Low, Hormone Recep
NCT06018337 · n=541 · Metastatic Breast Cancer · DualityBio Inc. w/ BioNTech SE · LEAPS ✓
data due · 17d
RGNX P3 est AFFINITY DUCHENNE: RGX-202 Gene Therapy in Participants With Duchenne Muscular Dystrophy (
NCT05693142 · n=65 · Duchenne Muscular Dystrophy · REGENXBIO Inc.
September 2026
data due · 2d
QURE Filing AMT-130 for Huntington's disease — BLA submission guided for Q3 2026 after uniQure and the FDA aligned in June 2026 on an accelerated-approval path; an approval decision would follow roughly mid-2027. source
manual entry · 2026-09-30 · guided
October 2026
3d
MRNA P2 est A Study of an Epstein-Barr Virus (EBV) Candidate Vaccine, mRNA-1189, in 10- to 30-Year-Old
NCT05164094 · n=867 · Epstein-Barr Virus Infection · ModernaTX, Inc. · LEAPS ✓
~13d
RGNX P3 est Pivotal 2 Study of RGX-314 Gene Therapy in Participants With nAMD
NCT05407636 · n=735 · AMD; nAMD; Wet Age-related Macular Degeneration · AbbVie w/ REGENXBIO Inc.
13d
SLDB P2 est Microdystrophin Gene Transfer Study in Adolescents and Children With DMD
NCT03368742 · n=12 · Duchenne Muscular Dystrophy · Solid Biosciences Inc.
28d
BNTX P2 est A Study of PM8002 Plus Nab-paclitaxel as First Line Therapy for TNBC
NCT05918133 · n=42 · TNBC · Biotheus Inc. · LEAPS ✓
29d
SRPT P3 est A Study to Compare Safety and Efficacy of High Doses of Eteplirsen in Participants With Du
NCT03992430 · n=160 · Muscular Dystrophy, Duchenne · Sarepta Therapeutics, Inc. · LEAPS ✓
November 2026
~44d
BNTX P2 est A Phase II Clinical Trial Comparing the Efficacy of RO7198457 Versus Watchful Waiting in P
NCT04486378 · n=327 · Colorectal Cancer Stage II; Colorectal Cancer Stage III · BioNTech SE w/ Genentech, Inc. · LEAPS ✓
~44d
ALNY PDUFA Cemdisiran, partnered with Regeneron, has an FDA target action date in November 2026 for generalized myasthenia gravis under priority review. source
manual entry · 2026-11-15 · guided
59d
MRNA P2 est A Study of mRNA-3745 in Adult and Pediatric Participants With Glycogen Storage Disease Typ
NCT05095727 · n=15 · Glycogen Storage Disease · ModernaTX, Inc. · LEAPS ✓
59d
QURE P2 est AMT-260 Gene Therapy Study in Adults With Unilateral Refractory Mesial Temporal Lobe Epile
NCT06063850 · n=12 · Mesial Temporal Lobe Epilepsy · UniQure Biopharma B.V. · LEAPS ✓
December 2026
60d
RNAC P2 est Descartes-08 for Patients With Systemic Lupus Erythematosus
NCT06038474 · n=6 · Systemic Lupus Erythematosus (SLE) · Cartesian Therapeutics
~74d
IONS P3 est A Study to Assess the Long-Term Safety and Efficacy of Donidalorsen in the Prophylactic Tr
NCT05392114 · n=154 · Hereditary Angioedema · Ionis Pharmaceuticals, Inc. · LEAPS ✓
~74d
RGNX P3 est Pivotal 1 Study of ABBV-RGX-314 (Also Known as RGX-314) Gene Therapy Administered Via Subr
NCT04704921 · n=671 · AMD; nAMD; Wet Age-related Macular Degeneration · AbbVie w/ REGENXBIO Inc.
~74d
NTRA P3 est Evaluating Novel Therapies in ctDNA Positive GI Cancers
NCT05482516 · n=20 · Colon Adenocarcinoma; Rectal Adenocarcinoma; Gastric Adenocarcinoma · Georgetown University w/ Genentech, Inc.; Natera, Inc. · LEAPS ✓
~74d
BEAM P2 est A Study Evaluating the Safety and Efficacy of BEAM-201 in Relapsed/Refractory T-Cell Acute
NCT05885464 · n=5 · Lymphoblastic Lymphoma; T-Cell Lymphoblastic Leukemia/Lymphoma; Lymphoblastic Leukemia · Beam Therapeutics Inc. · LEAPS ✓
~74d
LXEO P2 est Gene Therapy for ACM Due to a PKP2 Pathogenic Variant
NCT06109181 · n=10 · Arrhythmogenic Cardiomyopathy; PKP2-ACM; PKP2-ARVC · Lexeo Therapeutics
~74d
NTLA Filing Lonvo-z (NTLA-2002) for hereditary angioedema — full BLA submission guided for the second half of 2026 after the HAELO pivotal trial succeeded in April 2026; Intellia plans a first-half-2027 launch, which would be the first approved in-vivo CRISPR therapy. source
manual entry · 2026-12-15 · guided
89d
RNAC P3 est Investigating an mRNA CAR T-cell Therapy, Known as Descartes-08, as a Potential Approach t
NCT06799247 · n=128 · Myasthaenia Gravis · Cartesian Therapeutics
90d
SRPT P2 est Study of SRP-1003 in Participants With Type 1 Myotonic Dystrophy
NCT06138743 · n=78 · Myotonic Dystrophy 1 · Sarepta Therapeutics, Inc. · LEAPS ✓
January 2027
91d
BNTX P2 est A Study of PM8002 in Combination With Chemotherapy in Patients With NEN
NCT05879055 · n=31 · Neuroendocrine Neoplasm · Biotheus Inc. · LEAPS ✓
91d
IOVA P2 est E7 TCR-T Cell Immunotherapy for Human Papillomavirus (HPV) Associated Cancers
NCT05686226 · n=20 · Cervical Cancer; Throat Cancer; Oropharynx Cancer · Christian Hinrichs w/ National Cancer Institute (NCI); Iovance Biotherapeutics, Inc. · LEAPS ✓
115d
BNTX P3 est PM8002 in Combination With Paclitaxel Compared With Chemotherapy as Second-line Treatment
NCT06616532 · n=404 · SCLC · Biotheus Inc. · LEAPS ✓
118d
MRNA P3 est A Study of mRNA-1018-H5 Pandemic Influenza Vaccine in Healthy Adults
NCT07496450 · n=4050 · Influenza · ModernaTX, Inc. · LEAPS ✓
February 2027
136d
MRNA P3 est A Study to Investigate the Safety and Efficacy of mRNA-1403 in Participants ≥18 Years of A
NCT06592794 · n=37864 · Acute Gastroenteritis; Norovirus Acute Gastroenteritis · ModernaTX, Inc. · LEAPS ✓
March 2027
155d
MRNA P2 est A Study to Evaluate the Efficacy, Safety, and Immunogenicity of mRNA-1647 Cytomegalovirus
NCT05683457 · n=84 · Cytomegalovirus Infection · ModernaTX, Inc. · LEAPS ✓
161d
TSHA P2 est First-in-Human Study of TSHA-101 Gene Therapy for Treatment of Infantile Onset GM2 Ganglio
NCT04798235 · n=3 · Infantile GM2 Gangliosidosis (Disorder) · Dr. Anupam Sehgal w/ Taysha Gene Therapies, Inc.; GlycoNet
~164d
IONS P3 est CORE-OLE: A Study of Olezarsen (ISIS 678354) Administered Subcutaneously to Participants W
NCT05681351 · n=885 · Severe Hypertriglyceridemia · Ionis Pharmaceuticals, Inc. · LEAPS ✓
~164d
STOK P3 est A Double-blind Study Evaluating the Efficacy, Safety, and Tolerability of Zorevunersen in
NCT06872125 · n=170 · Dravet Syndrome · Stoke Therapeutics, Inc · LEAPS ✓
April 2027
~195d
IONS P2 est PrProfile: A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynami
NCT06153966 · n=85 · Prion Disease · Ionis Pharmaceuticals, Inc. · LEAPS ✓
203d
MRNA P2 est A Clinical Study of Intismeran Autogene (V940) Treatment and Pembrolizumab in People With
NCT06305767 · n=230 · Bladder Cancer · Merck Sharp & Dohme LLC w/ ModernaTX, Inc. · LEAPS ✓
207d
ALNY P2 est A Study to Evaluate ALN-2232 in Participants With Obesity
NCT07463846 · n=156 · Obesity · Alnylam Pharmaceuticals · LEAPS ✓
210d
RNA P2 est Ph2 Open-label Study of AOC 1044 in Duchenne Muscular Dystrophy Participants With Mutation
NCT06244082 · n=39 · DMD; Duchenne Muscular Dystrophy; Duchenne · Avidity Biosciences, Inc. · LEAPS ✓
210d
IOVA P2 est LN-145 or LN-145-S1 in Treating Patients With Relapsed or Refractory Ovarian Cancer, Tripl
NCT03449108 · n=30 · Bone Sarcoma; Dedifferentiated Chondrosarcoma; Giant Cell Tumor of Bone · M.D. Anderson Cancer Center w/ Iovance Biotherapeutics, Inc.; National Cancer Institute (NCI) · LEAPS ✓
May 2027
216d
SLDB P2 est A Study of SGT-003 Gene Therapy in Duchenne Muscular Dystrophy (INSPIRE DUCHENNE)
NCT06138639 · n=60 · Duchenne Muscular Dystrophy · Solid Biosciences Inc.
~225d
BNTX P2 est PM8002 (BNT327) in Combination With Chemotherapy in Patients With Metastatic Colorectal Ca
NCT07133750 · n=100 · CRC (Colorectal Cancer) · Biotheus Inc. w/ BioNTech SE · LEAPS ✓
238d
ALNY P2 est A Study to Evaluate ALN-4324 on Insulin Sensitivity in Adults With Type 2 Diabetes Mellitu
NCT07465224 · n=24 · Type 2 Diabetes Mellitus (T2DM) · Alnylam Pharmaceuticals · LEAPS ✓
241d
SRPT P3 est A Gene Transfer Therapy Study to Evaluate the Safety and Efficacy of Delandistrogene Moxep
NCT05881408 · n=148 · Duchenne Muscular Dystrophy · Sarepta Therapeutics, Inc. w/ Hoffmann-La Roche · LEAPS ✓
June 2027
247d
CRSP P3 est Evaluation of Safety and Efficacy of CTX001 in Pediatric Participants With Severe Sickle C
NCT05329649 · n=13 · Sickle Cell Disease; Hydroxyurea Failure; Hydroxyurea Intolerance · Vertex Pharmaceuticals Incorporated w/ CRISPR Therapeutics · LEAPS ✓
~256d
IONS P3 est A Study of Olezarsen (Formerly Known as AKCEA-APOCIII-LRX) Administered to Adults With Fam
NCT05185843 · n=24 · Familial Chylomicronemia Syndrome · Ionis Pharmaceuticals, Inc. · LEAPS ✓
~256d
BNTX P2 est A Randomized Clinical Trial Investigating the Safety, Reactogenicity, and Immunogenicity A
NCT07379580 · n=310 · Mpox (Monkeypox); Smallpox; Orthopoxvirus Infection · BioNTech SE w/ Coalition for Epidemic Preparedness Innovations · LEAPS ✓
~256d
BNTX P2 est Safety, Preliminary Effectiveness of BNT327, an Investigational Therapy for Patients With
NCT06449209 · n=110 · Extensive-stage Small-cell Lung Cancer; Small-cell Lung Cancer · BioNTech SE · LEAPS ✓
~256d
ARCT P2 est Safety, Tolerability and Efficacy Study of ARCT-032 in People With Cystic Fibrosis
NCT06747858 · n=33 · Cystic Fibrosis; CFTR Gene Mutation · Arcturus Therapeutics, Inc.
271d
ALNY P2 est HMBeacon: A Phase 2 Study to Evaluate ALN-6400 in Adult and Adolescent Female Patients Wit
NCT07575308 · n=24 · Von Willebrand Disease (VWD); Heavy Menstrual Bleeding (HMB) · Alnylam Pharmaceuticals · LEAPS ✓
July 2027
~286d
NTLA P3 est A Phase 3 Study of NTLA-2001 in ATTRv-PN
NCT06672237 · n=60 · Neuromuscular Disease; Neuromuscular Diseases (NMD); Neurodegenerative Disease · Intellia Therapeutics w/ Regeneron Pharmaceuticals · LEAPS ✓
~286d
BNTX P3 est PM8002 or Placebo Plus Nab-Paclitaxel as First-line Treatment in Inoperable Locally Advanc
NCT06419621 · n=392 · Triple Negative Breast Cancer(TNBC) · Biotheus Inc. · LEAPS ✓
August 2027
311d
ALNY P2 est A Phase 2 Trial of ALN-APP in Patients With Cerebral Amyloid Angiopathy
NCT06393712 · n=210 · Cerebral Amyloid Angiopathy · Alnylam Pharmaceuticals · LEAPS ✓
315d
BNTX P2 est First-in-human Study of DB-1305/BNT325 for Advanced/Metastatic Solid Tumors
NCT05438329 · n=1123 · Advanced Solid Tumor · DualityBio Inc. w/ BioNTech SE · LEAPS ✓
~317d
IONS P3 est REVEAL: A Phase 3 Study of Obudanersen (ION582) in Angelman Syndrome
NCT06914609 · n=156 · Angelman Syndrome · Ionis Pharmaceuticals, Inc. · LEAPS ✓
~317d
BNTX P2 est A Phase 1/2a Study of DB-1303/BNT323 in Advanced/Metastatic Solid Tumors
NCT05150691 · n=796 · HER2-positive Advanced Solid Tumor · DualityBio Inc. w/ BioNTech SE · LEAPS ✓
333d
BNTX P3 est ONC-392 Versus Docetaxel in Metastatic NSCLC That Progressed on PD-1/PD-L1 Inhibitors
NCT05671510 · n=630 · Non Small Cell Lung Cancer · OncoC4, Inc. w/ BioNTech SE · LEAPS ✓
333d
MRNA P2 est Open-Label Study of mRNA-3927 in Participants With Propionic Acidemia
NCT04159103 · n=77 · Propionic Acidemia · ModernaTX, Inc. · LEAPS ✓
333d
ALNY P2 est A Study to Evaluate ALN-4324 in Overweight to Obese Healthy Volunteers and in Overweight t
NCT06845202 · n=105 · Obese or Overweight Healthy Volunteers; Type 2 Diabetes Mellitus (T2DM) · Alnylam Pharmaceuticals · LEAPS ✓
September 2027
~348d
IONS P2 est A Study to Assess the Safety, Tolerability and Efficacy of ION775
NCT07604974 · n=72 · Hypertriglyceridemia; Severe Hypertriglyceridemia · Ionis Pharmaceuticals, Inc. · LEAPS ✓
~348d
IONS P2 est ATTUNE: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynami
NCT06430385 · n=48 · Methyl CpG Binding Protein 2 (MECP2) Duplication Syndrome · Ionis Pharmaceuticals, Inc. · LEAPS ✓
~348d
IOVA P2 est A Study to Investigate the Efficacy and Safety of an Infusion of IOV-4001 in Adult Partici
NCT05361174 · n=53 · Unresectable Melanoma; Metastatic Melanoma; Stage III Non-small Cell Lung Cancer · Iovance Biotherapeutics, Inc. · LEAPS ✓
5 routine trials hidden — strain updates, extensions, tracers
data due · 84d
BNTX P3 firm A Study to Learn About Variant-Adapted COVID-19 RNA Vaccine Candidate(s) in Healthy Childr
NCT05543616 · n=4338 · SARS-CoV-2 Virus; Severe Acute Respiratory Syndrome Coronavirus 2; COVID-19 · BioNTech SE w/ Pfizer · LEAPS ✓
data due · 70d
BNTX P3 firm A Study to Learn About BNT162b2 (LP.8.1)-Adapted Vaccine Against SARS-CoV-2 in Children 5
NCT07222384 · n=344 · COVID-19; SARS-COV-2 Infection · BioNTech SE w/ Pfizer · LEAPS ✓
data due · 64d
ILMN P3 firm Open-Label Study of 18F-mFBG for Imaging Neuroblastoma
NCT04724369 · n=43 · Neuroblastoma · Innervate Radiopharmaceuticals LLC (Formerly: Illumina Radiopharmaceuticals LLC) w/ New Approaches to Neuroblastoma Therapy Consortium; Memorial Sloan Kettering Cancer Center · LEAPS ✓
data due · 63d
BNTX P3 est A Study to Learn About a COVID-19 Vaccine in Healthy Adults 50 Through 64 Years of Age
NCT07300839 · n=5240 · COVID-19; SARS-COV-2 Infection · BioNTech SE w/ Pfizer · LEAPS ✓
201d
BNTX P3 est A Study of COVID-19 Vaccine(s) in Children and Adults
NCT07798648 · n=700 · COVID-19 Vaccines · BioNTech SE w/ Pfizer · LEAPS ✓
34 Phase 3 trials beyond the window — registry dates are unreliable for event-driven trials (MRNA’s INTerpath-001 carried a 2029 date and read out 2026-08-19)
408d
CRSP P3 est Evaluation of Safety and Efficacy of CTX001 in Pediatric Participants With Transfusion-Dep
NCT05356195 · n=16 · Beta-Thalassemia; Thalassemia; Genetic Diseases, Inborn · Vertex Pharmaceuticals Incorporated w/ CRISPR Therapeutics · LEAPS ✓
~439d
NTLA P3 est MAGNITUDE: A Phase 3 Study of NTLA-2001 in Participants With Transthyretin Amyloidosis Wit
NCT06128629 · n=1200 · Transthyretin Amyloidosis (ATTR) With Cardiomyopathy · Intellia Therapeutics w/ Regeneron Pharmaceuticals · LEAPS ✓
439d
WGS P3 est Trial of Therapeutic Cancer Vaccine OSE2101 in Patients With Non-Small Cell Lung Cancer an
NCT06472245 · n=363 · Patients With Non-Small Cell Lung Cancer · OSE Immunotherapeutics w/ Exystat; GeneDx · LEAPS ✓
451d
ALNY P3 est TRITON-PN: A Study to Evaluate the Efficacy and Safety of Nucresiran in Patients With Here
NCT07223203 · n=125 · Hereditary Transthyretin-Mediated Amyloidosis With Polyneuropathy; hATTR-PN · Alnylam Pharmaceuticals · LEAPS ✓
~501d
IONS P3 est A Study of Olezarsen (Formerly Known as AKCEA-APOCIII-LRx) in Participants With Familial C
NCT05130450 · n=60 · Familial Chylomicronemia Syndrome · Ionis Pharmaceuticals, Inc. · LEAPS ✓
~530d
BNTX P3 est A Clinical Study of the Anti-cancer Effects of an Investigational Therapy or Chemotherapy
NCT06340568 · n=480 · Endometrial Cancer · BioNTech SE w/ DualityBio Inc.; BioNTech (Shanghai) Pharmaceuticals Co., Ltd. · LEAPS ✓
516d
IOVA P3 est Study to Investigate Lifileucel Regimen Plus Pembrolizumab Compared With Pembrolizumab Alo
NCT05727904 · n=670 · Metastatic Melanoma; Unresectable Melanoma; Melanoma · Iovance Biotherapeutics, Inc. · LEAPS ✓
546d
ALNY P3 est A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopa
NCT06679946 · n=700 · Transthyretin Amyloidosis (ATTR) With Cardiomyopathy · Alnylam Pharmaceuticals · LEAPS ✓
576d
RGNX P3 est RGX-121-3102 Gene Therapy in Participants With MPS II (Hunter Syndrome)
NCT07236606 · n=2 · MPS II; Hunter Syndrome (MPS II) · REGENXBIO Inc.
~591d
IONS P3 est CHAMPION: A Study to Evaluate the Efficacy and Safety of Obudanersen (ION582) in Children
NCT07782827 · n=30 · Angelman Syndrome · Ionis Pharmaceuticals, Inc. · LEAPS ✓
~591d
RNA P3 est A Study to Evaluate Del-brax (Also Referred to as AOC 1020) in Participants With FSHD
NCT07038200 · n=200 · Facioscapulohumeral Muscular Dystrophy; FSHD; FSHD - Facioscapulohumeral Muscular Dystrophy · Avidity Biosciences, Inc. · LEAPS ✓
~683d
BNTX P3 est A Clinical Trial Investigating the Safety, Tolerability, and Therapeutic Effects of BNT113
NCT04534205 · n=358 · Unresectable Head and Neck Squamous Cell Carcinoma; Metastatic Head and Neck Cancer; Recurrent Head and Neck Cancer · BioNTech SE · LEAPS ✓
730d
GH P3 est Continuous or Intermittent Cetuximab Plus FOLFIRI as First-line Treatment in RAS/BRAF Wild
NCT07004413 · n=267 · Colorectal Cancer Metastatic · Charite University, Berlin, Germany w/ Guardant Health, Inc.; Merck KGaA, Darmstadt, Germany · LEAPS ✓
~805d
BNTX P3 est Safety and Efficacy of BNT327, an Investigational Therapy in Combination With Chemotherapy
NCT06712355 · n=621 · Extensive-stage Small-cell Lung Cancer · BioNTech SE w/ Bristol-Myers Squibb · LEAPS ✓
~836d
BNTX P3 est Safety, Efficacy, and Pharmacokinetics of BNT327 in Combination With Chemotherapy and Othe
NCT06712316 · n=1580 · Non-small Cell Lung Cancer · BioNTech SE w/ Bristol-Myers Squibb · LEAPS ✓
~836d
SLDB P3 est A Study of SGT-003 Gene Therapy in Ambulant Males With Duchenne Muscular Dystrophy (IMPACT
NCT07160634 · n=80 · Duchenne Muscular Dystrophy · Solid Biosciences Inc.
890d
NTRA P3 est Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease
NCT05174169 · n=1912 · Stage III Colon Cancer · NRG Oncology w/ Natera, Inc.; National Cancer Institute (NCI) · LEAPS ✓
~956d
RNA P3 est A Phase 3 Study to Evaluate the Safety and Efficacy of AOC 1044 (Also Referred to as Delpa
NCT07587242 · n=70 · Muscular Dystrophies; Muscular Dystrophies (Duchenne, Becker, Myotonic Dystrophy); Muscular Disorders, Atrophic · Avidity Biosciences, Inc. · LEAPS ✓
~987d
IONS P3 est Donidalorsen Treatment in Children With Hereditary Angioedema
NCT07298447 · n=20 · Hereditary Angioedema (HAE) · Ionis Pharmaceuticals, Inc. · LEAPS ✓
~1048d
IONS P3 est An Extension Study to Assess Long-Term Safety of Eplontersen in Adults With Transthyretin-
NCT05667493 · n=1400 · Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM) · Ionis Pharmaceuticals, Inc. w/ AstraZeneca · LEAPS ✓
~1048d
IONS P3 est A Study to Assess the Long-Term Safety and Efficacy of Eplontersen (Formerly Known as ION-
NCT05071300 · n=151 · Hereditary Transthyretin-Mediated Amyloid Polyneuropathy · Ionis Pharmaceuticals, Inc. · LEAPS ✓
1120d
MRNA P3 est A Clinical Study of Intismeran Autogene (V940) Plus Pembrolizumab in People With High-Risk
NCT05933577 · n=1089 · Melanoma · Merck Sharp & Dohme LLC w/ ModernaTX, Inc. · LEAPS ✓
~1170d
BNTX P3 est ROSETTA Breast-01: The Effects and Safety of Pumitamig in Patients With Triple-Negative Br
NCT07173751 · n=558 · Breast Neoplasms · BioNTech SE w/ Bristol-Myers Squibb · LEAPS ✓
1219d
BNTX P3 est A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy
NCT07221357 · n=990 · Untreated, Unresectable, or Metastatic Colorectal Cancer · Bristol-Myers Squibb w/ BioNTech SE · LEAPS ✓
1334d
ALNY P3 est TRITON-CM: A Study to Evaluate Nucresiran in Patients With Transthyretin Amyloidosis With
NCT07052903 · n=1750 · Transthyretin Amyloidosis With Cardiomyopathy · Alnylam Pharmaceuticals · LEAPS ✓
1362d
MRNA P3 est A Study of Intismeran Autogene (V940) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pem
NCT06077760 · n=868 · Non-small Cell Lung Cancer · Merck Sharp & Dohme LLC w/ ModernaTX, Inc. · LEAPS ✓
~1413d
IONS P3 est A Study of Olezarsen for the Treatment of Familial Chylomicronemia Syndrome (FCS) in Pedia
NCT07727538 · n=12 · Familial Chylomicronemia Syndrome · Ionis Pharmaceuticals, Inc. · LEAPS ✓
1447d
BNTX P3 est A Study to Evaluate Pumitamig Versus Durvalumab Following Concurrent Chemoradiation Therap
NCT07361497 · n=850 · Non-small Cell Lung Cancer (NSCLC) · Bristol-Myers Squibb w/ BioNTech SE · LEAPS ✓
1452d
ALNY P3 est Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Establ
NCT07181109 · n=11000 · High Risk Cardiovascular Disease; Hypertension; High Cardiovascular Risk · Alnylam Pharmaceuticals w/ Hoffmann-La Roche · LEAPS ✓
~1474d
RNA P3 est Global Open-Label Extension Study of Del-desiran for the Treatment of DM1
NCT07008469 · n=199 · Myotonic Dystrophy Type 1; DM1; Myotonic Dystrophy · Avidity Biosciences, Inc. · LEAPS ✓
1498d
BNTX P3 est A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy
NCT07221149 · n=690 · Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma · Bristol-Myers Squibb w/ BioNTech SE · LEAPS ✓
~1597d
BNTX P3 est A Phase III Trial of BNT324 Versus Docetaxel in Metastatic Castration-resistant Prostate C
NCT07365995 · n=736 · Metastatic Castration-resistant Prostate Cancer · BioNTech SE w/ BioNTech (Shanghai) Pharmaceuticals Co., Ltd.; DualityBio Inc. · LEAPS ✓
~1717d
TSHA P3 est Safety and Preliminary Efficacy of TSHA-102 Gene Therapy in Pediatric Females Aged >2 to <
NCT07480564 · n=4 · Rett Syndrome · Taysha Gene Therapies, Inc.
~1717d
TSHA P3 est A Phase 1/2/3 Study of TSHA-102 Gene Therapy in Females With Rett Syndrome (REVEAL Pivotal
NCT05606614 · n=17 · Rett Syndrome · Taysha Gene Therapies, Inc.
Candidates beyond the watchlist — weekly sweep, last ran 2026-09-27

A candidate is a sponsor or collaborator on an industry Phase 3 that maps to a US-listed ticker and is neither on the watchlist nor big pharma. Say the word to add one (or mark it in universe.yaml dispositions).

IVBXFInnovent Biologics Inc/ADR
first seen 2026-08-19 · nearest window 2026-09-30
NCT05116462 Neoadjuvant and Adjuvant Therapy Studies of Sindilizumab in Resectable Lung Cancer (Non-Small Cell Lung Cancer · 2026-09-30 · via “cell therapy”)
SKBBYSichuan Kelun-Biotech Biopharmaceutical Co., Ltd./ADR
first seen 2026-08-19 · nearest window 2026-11
NCT06448312 A Study of SKB264 in Combination With Pembrolizumab Versus Pembrolizumab in Patients With (Non-Small Cell Lung Cancer · 2026-11 · via “cell therapy”)
NCT06711900 A Study of SKB264 in Combination With Pembrolizumab Versus Chemotherapy in Combination Wit (Non-Small Cell Lung Cancer · 2026-12 · via “cell therapy”)
NCT06670196 A Study of SKB264 in Combination With Osimertinib Versus Osimertinib in Patients With Epid (Non-Small Cell Lung Cancer · 2027-05 · via “cell therapy”)
KPTIKaryopharm Therapeutics Inc.
first seen 2026-08-19 · nearest window 2026-12
NCT04442022 A Study of Rituximab-Gemcitabine-Dexamethasone-Platinum (R-GDP) With or Without Selinexor (Relapsed/Refractory Diffuse Large B-cell Lymphoma · 2026-12 · via “cell therapy”)
HROWHARROW, INC.
first seen 2026-09-27 · nearest window 2026-12
NCT07832552 A Phase 3 Study Evaluating the Safety and Efficacy of TRIESENCE® (Injectable Suspension) f (Postoperative Ocular Inflammation; Postoperative Ocular Pain · 2026-12 · via “cell therapy”)
SVASINOVAC BIOTECH LTD
first seen 2026-08-19 · nearest window 2026-12-30
NCT07055295 Immunogenicity and Safety of Rabies Vaccine (Serum-free Vero Cell) in a Pre-exposure Proph (Rabies · 2026-12-30 · via “cell therapy”)
NCT07793227 Phase Ⅲ Clinical Trial of an Inactivated Hepatitis A Vaccine (Hepatitis A Vaccine · 2027-09-15 · via “cell therapy”)
ONCBeOne Medicines Ltd.
first seen 2026-08-30 · nearest window 2026-12-31
NCT04170283 A Study to Evaluate Long-term Safety of Zanubrutinib Regimens in Participants With B-Cell (B-cell Malignancies · 2026-12-31 · via “cell therapy”)
OCGNOcugen, Inc.
first seen 2026-08-19 · nearest window 2027-02-12
NCT06388200 A Phase 3 Study Of OCU400 Gene Therapy for the Treatment Of Retinitis Pigmentosa (Retinitis Pigmentosa · 2027-02-12 · via “gene therapy”)
HURATuHURA Biosciences, Inc./NV
first seen 2026-08-19 · nearest window 2027-03-31
NCT06947928 Placebo-Controlled Trial of IFx-Hu2.0 Followed By Pembrolizumab In Checkpoint Inhibitor Na (Advanced Or Metastatic Merkel Cell Carcinoma · 2027-03-31 · via “cell therapy”)
FDMT4D Molecular Therapeutics, Inc.
first seen 2026-08-19 · nearest window 2027-06
NCT06864988 4D-150 in Patients With Macular Neovascularization Secondary to Age-Related Macular Degene (Macular Neovascularization Secondary to Age-Related Macular Degeneration · 2027-06 · via “gene therapy”)
DNLIDenali Therapeutics Inc.
first seen 2026-08-19 · nearest window 2027-06
NCT06075537 An Extension Study of the Long-Term Safety, Tolerability, and Efficacy of Tividenofusp Alf (Mucopolysaccharidosis II · 2027-06 · via “gene therapy”)
MESOMESOBLAST LTD
first seen 2026-08-19 · nearest window 2027-07
NCT06325566 Efficacy and Safety of Rexlemestrocel-L Combined With HA* in Participants With Moderate to (Degenerative Disc Disease · 2027-07 · via “cell therapy”)
MAIAMAIA Biotechnology, Inc.
first seen 2026-08-19 · nearest window 2027-07-31
NCT06908304 A Phase III Study With THIO + Cemiplimab vs Chemotherapy as 3rd Line Treatment in Advanced (Carcinoma, Non-Small -Cell Lung · 2027-07-31 · via “cell therapy”)
RAREUltragenyx Pharmaceutical Inc.
first seen 2026-08-19 · nearest window 2027-08
NCT04360265 Follow-up Study of AAV-Mediated Gene Transfer (UX111; Previously Known as ABO-102) for MPS (Mucopolysaccharidosis IIIA; MPS IIIA; Sanfilippo Syndrome · 2027-08 · via “gene therapy”)
NCT05345171 Clinical Study of DTX301 AAV-Mediated Gene Transfer for Ornithine Transcarbamylase (OTC) D (OTC Deficiency · 2027-09 · via “gene therapy”)
TLXTelix Pharmaceuticals Ltd
first seen 2026-09-06 · nearest window 2027-08-31
NCT07197580 Phase 3 Study to Assess Safety and Efficacy of 177Lu-TLX250 in Advanced Relapsed or Recurr (ccRCC; Renal Cell Carcinoma (Kidney Cancer); Renal Cell Carcinoma (RCC) · 2027-08-31 · via “cell therapy”)
KYTXKyverna Therapeutics, Inc.
first seen 2026-09-06 · nearest window 2027-09
NCT06193889 KYSA-6: A Study of Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy, in Patients With Ge (Myasthenia Gravis; Generalized Myasthenia Gravis · 2027-09 · via “cell therapy”)
Full sponsor table (60 names — majors, watchlist and unmapped greyed)
7
Merck Sharp & Dohme LLC · major
6
AstraZeneca · major
5
Novartis Pharmaceuticals · major
4
Qilu Pharmaceutical Co., Ltd. · unmapped
4
Changchun GeneScience Pharmaceutical Co., Ltd. · unmapped
3
Akeso · unmapped
3
Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. · candidate · SKBBY
3
Amgen · major
2
Daiichi Sankyo · major
2
Shanghai JMT-Bio Inc. · unmapped
2
AbbVie · major
2
REGENXBIO Inc. · watchlist
2
Chia Tai Tianqing Pharmaceutical Group Co., Ltd. · unmapped
2
Takeda · major
2
Sichuan Baili Pharmaceutical Co., Ltd. · unmapped
2
Baili-Bio (Chengdu) Pharmaceutical Co., Ltd. · unmapped
2
Suzhou Suncadia Biopharmaceuticals Co., Ltd. · unmapped
2
Sinovac Biotech Co., Ltd · candidate · SVA
2
Hoffmann-La Roche · major
2
Vertex Pharmaceuticals Incorporated · major
2
Regeneron Pharmaceuticals · major
2
Ultragenyx Pharmaceutical Inc · candidate · RARE
1
Innovent Biologics (Suzhou) Co. Ltd. · candidate · IVBXF
1
Hansoh BioMedical R&D Company · unmapped
1
Novadip Biosciences · unmapped
1
Privo Technologies · unmapped
1
National Cancer Institute (NCI) · unmapped
1
Han Xu, M.D., Ph.D., FAPCR, Medical Director,, IRB Chair · unmapped
1
UnitedHealthcare · unmapped
1
European Network of Gynaecological Oncological Trial Groups (ENGOT) · unmapped
1
Gynecologic Oncology Group · unmapped
1
CAS Lamvac (Guangzhou) Biomedical Technology Co., Ltd. · unmapped
1
The Third Affiliated Hospital of Southern Medical University · unmapped
1
Cytopeutics Sdn. Bhd. · unmapped
1
National University of Malaysia · unmapped
1
TVAX Biomedical · unmapped
1
Mabscale, LLC · unmapped
1
Wuxi Cellular Biopharmaceutical Group Ltd. · unmapped
1
Breathe Biologics, Inc. · unmapped
1
Karyopharm Therapeutics Inc · candidate · KPTI
1
Harrow Inc · candidate · HROW
1
Cook MyoSite · unmapped
1
Shanghai Vitalgen BioPharma Co., Ltd. · unmapped
1
Boehringer Ingelheim · major
1
CSPC Megalith Biopharmaceutical Co.,Ltd. · unmapped
1
Adverum Biotechnologies, Inc. · major
1
Jiangsu Topcel-KH Pharmaceutical Co., Ltd. · unmapped
1
Cartesian Therapeutics · watchlist
1
Beijing Konruns Pharmaceutical Co., Ltd. · unmapped
1
Xynomic Pharmaceuticals, Inc. · unmapped
1
GeneCradle Inc · unmapped
1
BeOne Medicines · candidate · ONC
1
West China Hospital · unmapped
1
Gilead Sciences · major
1
iVascular S.L.U. · unmapped
1
Takeda Development Center Americas, Inc. · major
1
Biotheus Inc. · unmapped
1
Ocugen · candidate · OCGN
1
Acerta Pharma BV · unmapped
1
Grace Science, LLC · unmapped
Journal — the running record; a month from now the context is here
2026-08-20 — UI v1 rejected; redesign spec written

Owner's verdict on the v1 dashboard: a complete shit show — can't keep track of or find anything. Fair. v1 renders all 94 trials as one stack of dense tables with no triage, no per-name view, no search, and the journal buried at the bottom.

  • Full redesign spec written at stockradar/design/ui-spec.md: five views (Today / Names / Calendar / Candidates / More), global search, group filter chips, a rolling 14-day activity feed, routine-trial noise hiding, ticker cards with a per-name detail panel, bottom tab bar on phone, strict color discipline. Vanilla JS now allowed; still one static file, no framework.
  • The spec went to Claude Design for a visual draft; implementation in render.py follows once the design is settled.
  • The main Signal Radar dashboard sidebar now links to Catalysts (signal_radar/preview.py, _NAV_MAIN).
2026-08-19 — Radar built and deployed

Goal set: find and be positioned for genomics innovation over the next 3–5 years. The radar exists so that nothing discussed in a Claude session gets lost: findings land here in the journal, candidates land in the candidates section with a first-seen date, and the calendar tracks every known catalyst.

What went live today

  • The Phase 3 screener was validated live against ClinicalTrials.gov (its query syntax works as written) and deployed unchanged, wrapped by radar_run.py. Nightly run at 05:30 ET weekdays; discovery sweep plus candidate mapping on Sundays.
  • The wrapper adds what the raw screener lacked: a Phase 2 pass for the therapeutic names (the biggest platform jumps come from early data, not Phase 3), estimated-versus-actual completion-date tracking (a flip to "actual" means last patient visit done, topline typically inside one to four months), sponsor-and-collaborator ticker mapping through SEC EDGAR so discovery surfaces tradeable names instead of raw sponsor strings, and MarketData-based LEAPS availability per name for long-horizon positioning.
  • Data providers confirmed: marketdata.app is primary (token already lives on this box and the account is IP-locked here, which is correct) and Databento is the backup when MarketData credits run out. The IV term-structure scan around catalysts is built but off by default to protect the MarketData credit ceiling — flip iv_scan: true in universe.yaml to enable.

First findings (from the live runs)

  • The 12-month Phase 3 window holds 17 trials across only 9 of 30 watchlist names. Nearest: REGENXBIO's Duchenne gene therapy (September 2026), the AbbVie-run RGX-314 eye trials (October and December 2026), Sarepta's high-dose eteplirsen (end of October 2026).
  • The discovery sweep surfaced two apparently-new names; the tradeability check then killed one of them, which is the system working: **Cartesian Therapeutics (RNAC)** — mRNA CAR-T for myasthenia gravis, pivotal window November 2026, options listed but only out to February 2027 — was added to the watchlist. Adverum looked like a find, but SEC EDGAR and MarketData both came back empty, and it turned out Eli Lilly acquired Adverum ($3.56/share plus CVR, delisted 2025-12-09) — before the pivotal readout, which is the M&A-before-data pattern to expect more of in gene therapy.
  • Same check exposed a stale name in the original watchlist: Abbott completed its $21B takeover of Exact Sciences on 2026-03-23, so EXAS is delisted too. Both now live in the delisted list in universe.yaml.
  • Regulatory picture (from today's search, sources in events.yaml): Intellia's HAELO pivotal for hereditary angioedema succeeded in April 2026; BLA guided for H2 2026, launch planned H1 2027 — would be the first in-vivo CRISPR approval. Note the FDA also placed a hold on two Intellia nex-z (ATTR) trials earlier in 2026 — the registry may lag on this; treat NTLA's 2027 ATTR timeline as soft. uniQure got FDA alignment in June 2026 for an accelerated-approval BLA on AMT-130 (Huntington's), submission guided Q3 2026. Alnylam/Regeneron's cemdisiran has a November 2026 FDA action date.

Post-mortem, same evening: would this have flagged today's MRNA double?

Honest answer: no, not as built this morning — and the reason reshaped the radar. Moderna roughly doubled today on INTerpath-001: the Merck-partnered individualized mRNA cancer vaccine plus Keytruda met its endpoints in resected melanoma — the first positive Phase 3 for any mRNA cancer therapy (FDA also cleared the mFLUSIVA flu shot the same day). The trial WAS reachable by our sponsor query (ModernaTX is listed as collaborator under Merck's lead on NCT05933577), but its registry primary-completion date is October 2029 — today's result came from an event-driven interim analysis, three years ahead of the registry date, so a forward completion-date window could never contain it. Meanwhile the readout was guided by the companies for 2026, meaning the guidance layer (events.yaml) was the right net and simply hadn't been fed.

Three changes went in tonight:

  • Beyond-window pass: every watchlist name's Phase 3 trials out to five years now render in their own section, so standing heavyweights like INTerpath-001 are visible even when the registry date is far and unreliable.
  • Lookback window: trials whose primary completion passed in the last ~4 months (including newly COMPLETED ones) now stay on the calendar marked "data due" — completion-to-topline is the hottest zone and the old filter structurally dropped it.
  • Standing chore, not yet automated: once a quarter (earnings season), sweep each watchlist name's guidance for "data expected in ..." statements into events.yaml. The registry times the ordinary readouts; only guidance times the big event-driven ones.

Also from tonight: a daily email brief now goes out after each run — changes, data-due list, everything inside 30 days, new candidates — via the same Resend account the Signal Radar digest uses.

Decisions

  • Frontend is a static page at radar.gpt.cafe/catalysts/ — no framework, no build chain, so it will still render in five years.
  • Diagnostics names stay on the radar but their real catalysts are coverage and guideline decisions, not trials; don't read their empty trial rows as "no catalysts".
  • MarketData enrichment kept deliberately cheap (expirations only, cached a day). The screener file itself stays untouched per the deployment brief.
The 3–5 year map

Gene editing

The first wave of one-time in-vivo editing treatments is crossing from trials into approvals between now and 2028. Intellia's hereditary angioedema program read out positive in April 2026 and is heading for the first in-vivo CRISPR approval; base and prime editing sit a few years behind with their first clinical proof points. These names move violently on early human data, not just Phase 3.

mRNA & individualized therapy

Beyond vaccines, the bet is individualized treatment — cancer vaccines tailored per patient and mRNA used as a drug. Partnered programs often run under the pharma partner's name (Merck runs the key Moderna oncology trials), so the discovery sweep is the backstop here.

RNA silencing & antisense

The most de-risked platform in the group: Alnylam and Ionis already sell approved drugs and fund broad pipelines from revenue. The 3–5 year story is expansion from rare disease into large populations (cardio, metabolic, neuro), where a single win re-rates the platform.

Gene therapy (AAV)

Highest torque and highest risk: single-asset companies where one readout or FDA meeting can halve or double the stock. uniQure's Huntington's program reaching the FDA under accelerated approval is the bellwether for the whole class; Sarepta is the cautionary tale on regulatory whiplash. Big pharma is already shopping here — Lilly took Adverum out in late 2025 before its pivotal even read out.

Cell therapy

Engineered-cell treatments moving from blood cancers into solid tumors and autoimmune disease. Manufacturing economics decide the winners as much as the science does.

Diagnostics & sequencing

These names rarely jump on trial readouts — their catalysts are Medicare coverage decisions, guideline inclusions, and earnings. The trial radar keeps them for coverage, but watch reimbursement news, not Phase 3 dates. Consolidation is live here too — Abbott closed its $21B Exact Sciences takeover in March 2026.

Data: ClinicalTrials.gov v2, SEC EDGAR, marketdata.app (Databento backup). Raw: latest.csv · latest.json. Sources in ~/optionsradar/stockradar/; nightly 05:30 ET weekdays, discovery Sundays; add tickers in universe.yaml, FDA dates in events.yaml, notes in journal/ — or ask Claude.