Registry dates slip constantly — the feed is the signal; confirm against company guidance before positioning.
IONSIonis Pharmaceuticals · RNAdata due · 107ddata due · 2026-06-178 in window · 6 beyondLEAPS ✓ to 2029-01-19
NCT04768972 · n=89 · Amyotrophic Lateral Sclerosis · Ionis Pharmaceuticals, Inc.
NCT05392114 · n=154 · Hereditary Angioedema · Ionis Pharmaceuticals, Inc.
NCT05681351 · n=885 · Severe Hypertriglyceridemia · Ionis Pharmaceuticals, Inc.
NCT06153966 · n=85 · Prion Disease · Ionis Pharmaceuticals, Inc.
NCT05185843 · n=24 · Familial Chylomicronemia Syndrome · Ionis Pharmaceuticals, Inc.
NCT06914609 · n=156 · Angelman Syndrome · Ionis Pharmaceuticals, Inc.
NCT07604974 · n=72 · Hypertriglyceridemia; Severe Hypertriglyceridemia · Ionis Pharmaceuticals, Inc.
NCT06430385 · n=48 · Methyl CpG Binding Protein 2 (MECP2) Duplication Syndrome · Ionis Pharmaceuticals, Inc.
NCT05130450 · n=60 · Familial Chylomicronemia Syndrome · Ionis Pharmaceuticals, Inc.
NCT07782827 · n=30 · Angelman Syndrome · Ionis Pharmaceuticals, Inc.
NCT07298447 · n=20 · Hereditary Angioedema (HAE) · Ionis Pharmaceuticals, Inc.
NCT05667493 · n=1400 · Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM) · Ionis Pharmaceuticals, Inc. w/ AstraZeneca
NCT05071300 · n=151 · Hereditary Transthyretin-Mediated Amyloid Polyneuropathy · Ionis Pharmaceuticals, Inc.
NCT07727538 · n=12 · Familial Chylomicronemia Syndrome · Ionis Pharmaceuticals, Inc.
RNAAvidity Biosciences · RNAdata due · 71ddata due · 2026-07-232 in window · 3 beyondLEAPS ✓ to 2028-01-21
NCT06411288 · n=159 · DM1; Myotonic Dystrophy; Myotonic Dystrophy 1 · Avidity Biosciences, Inc.
NCT06244082 · n=39 · DMD; Duchenne Muscular Dystrophy; Duchenne · Avidity Biosciences, Inc.
NCT07038200 · n=200 · Facioscapulohumeral Muscular Dystrophy; FSHD; FSHD - Facioscapulohumeral Muscular Dystrophy · Avidity Biosciences, Inc.
NCT07587242 · n=70 · Muscular Dystrophies; Muscular Dystrophies (Duchenne, Becker, Myotonic Dystrophy); Muscular Disorders, Atrophic · Avidity Biosciences, Inc.
NCT07008469 · n=199 · Myotonic Dystrophy Type 1; DM1; Myotonic Dystrophy · Avidity Biosciences, Inc.
MRNAModerna · mRNAdata due · 70ddata due · 2026-07-248 in window · 2 beyondLEAPS ✓ to 2029-01-19
NCT06067230 · n=1153 · Respiratory Syncytial Virus · ModernaTX, Inc.
NCT05164094 · n=867 · Epstein-Barr Virus Infection · ModernaTX, Inc.
NCT05095727 · n=15 · Glycogen Storage Disease · ModernaTX, Inc.
NCT07496450 · n=4050 · Influenza · ModernaTX, Inc.
NCT06592794 · n=37864 · Acute Gastroenteritis; Norovirus Acute Gastroenteritis · ModernaTX, Inc.
NCT05683457 · n=84 · Cytomegalovirus Infection · ModernaTX, Inc.
NCT06305767 · n=230 · Bladder Cancer · Merck Sharp & Dohme LLC w/ ModernaTX, Inc.
NCT04159103 · n=77 · Propionic Acidemia · ModernaTX, Inc.
NCT05933577 · n=1089 · Melanoma · Merck Sharp & Dohme LLC w/ ModernaTX, Inc.
NCT06077760 · n=868 · Non-small Cell Lung Cancer · Merck Sharp & Dohme LLC w/ ModernaTX, Inc.
“Therapeutics (RNAC)** — mRNA CAR-T for myasthenia gravis, pivotal window” open →
BNTXBioNTech · mRNAdata due · 51ddata due · 2026-08-1212 in window · 9 beyond · 4 routineLEAPS ✓ to 2029-01-19
NCT06018337 · n=541 · Metastatic Breast Cancer · DualityBio Inc. w/ BioNTech SE
NCT05918133 · n=42 · TNBC · Biotheus Inc.
NCT04486378 · n=327 · Colorectal Cancer Stage II; Colorectal Cancer Stage III · BioNTech SE w/ Genentech, Inc.
NCT05879055 · n=31 · Neuroendocrine Neoplasm · Biotheus Inc.
NCT06616532 · n=404 · SCLC · Biotheus Inc.
NCT07133750 · n=100 · CRC (Colorectal Cancer) · Biotheus Inc. w/ BioNTech SE
NCT07379580 · n=310 · Mpox (Monkeypox); Smallpox; Orthopoxvirus Infection · BioNTech SE w/ Coalition for Epidemic Preparedness Innovations
NCT06449209 · n=110 · Extensive-stage Small-cell Lung Cancer; Small-cell Lung Cancer · BioNTech SE
NCT06419621 · n=392 · Triple Negative Breast Cancer(TNBC) · Biotheus Inc.
NCT05150691 · n=796 · HER2-positive Advanced Solid Tumor · DualityBio Inc. w/ BioNTech SE
NCT05438329 · n=1123 · Advanced Solid Tumor · DualityBio Inc. w/ BioNTech SE
NCT05671510 · n=630 · Non Small Cell Lung Cancer · OncoC4, Inc. w/ BioNTech SE
NCT06340568 · n=480 · Endometrial Cancer · BioNTech SE w/ DualityBio Inc.; BioNTech (Shanghai) Pharmaceuticals Co., Ltd.
NCT04534205 · n=358 · Unresectable Head and Neck Squamous Cell Carcinoma; Metastatic Head and Neck Cancer; Recurrent Head and Neck Cancer · BioNTech SE
NCT06712355 · n=621 · Extensive-stage Small-cell Lung Cancer · BioNTech SE w/ Bristol-Myers Squibb
NCT06712316 · n=1580 · Non-small Cell Lung Cancer · BioNTech SE w/ Bristol-Myers Squibb
NCT07173751 · n=558 · Breast Neoplasms · BioNTech SE w/ Bristol-Myers Squibb
NCT07221357 · n=990 · Untreated, Unresectable, or Metastatic Colorectal Cancer · Bristol-Myers Squibb w/ BioNTech SE
NCT07361497 · n=850 · Non-small Cell Lung Cancer (NSCLC) · Bristol-Myers Squibb w/ BioNTech SE
NCT07221149 · n=690 · Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma · Bristol-Myers Squibb w/ BioNTech SE
NCT07365995 · n=736 · Metastatic Castration-resistant Prostate Cancer · BioNTech SE w/ BioNTech (Shanghai) Pharmaceuticals Co., Ltd.; DualityBio Inc.
4 routine trials (strain updates, extensions, tracers)
NCT05543616 · n=4338 · SARS-CoV-2 Virus; Severe Acute Respiratory Syndrome Coronavirus 2; COVID-19 · BioNTech SE w/ Pfizer
NCT07222384 · n=344 · COVID-19; SARS-COV-2 Infection · BioNTech SE w/ Pfizer
NCT07300839 · n=5240 · COVID-19; SARS-COV-2 Infection · BioNTech SE w/ Pfizer
NCT07798648 · n=700 · COVID-19 Vaccines · BioNTech SE w/ Pfizer
RGNXREGENXBIO · AAVdata due · 17ddata due · 2026-093 in window · 1 beyondoptions to 2027-04-16 · no LEAPS
NCT05693142 · n=65 · Duchenne Muscular Dystrophy · REGENXBIO Inc.
NCT05407636 · n=735 · AMD; nAMD; Wet Age-related Macular Degeneration · AbbVie w/ REGENXBIO Inc.
NCT04704921 · n=671 · AMD; nAMD; Wet Age-related Macular Degeneration · AbbVie w/ REGENXBIO Inc.
NCT07236606 · n=2 · MPS II; Hunter Syndrome (MPS II) · REGENXBIO Inc.
“names. Nearest: REGENXBIO's Duchenne gene therapy (September 2026), the” open →
SLDBSolid Biosciences · AAV~13dP2 · 2026-10-152 in window · 1 beyondoptions to 2027-03-19 · no LEAPS
NCT03368742 · n=12 · Duchenne Muscular Dystrophy · Solid Biosciences Inc.
NCT06138639 · n=60 · Duchenne Muscular Dystrophy · Solid Biosciences Inc.
NCT07160634 · n=80 · Duchenne Muscular Dystrophy · Solid Biosciences Inc.
SRPTSarepta Therapeutics · AAV~29dP3 · 2026-10-313 in windowLEAPS ✓ to 2029-01-19
NCT03992430 · n=160 · Muscular Dystrophy, Duchenne · Sarepta Therapeutics, Inc.
NCT06138743 · n=78 · Myotonic Dystrophy 1 · Sarepta Therapeutics, Inc.
NCT05881408 · n=148 · Duchenne Muscular Dystrophy · Sarepta Therapeutics, Inc. w/ Hoffmann-La Roche
ALNYAlnylam Pharmaceuticals · RNA~44dPDUFA · 2026-11-155 in window · 4 beyondLEAPS ✓ to 2029-01-19
NCT07463846 · n=156 · Obesity · Alnylam Pharmaceuticals
NCT07465224 · n=24 · Type 2 Diabetes Mellitus (T2DM) · Alnylam Pharmaceuticals
NCT07575308 · n=24 · Von Willebrand Disease (VWD); Heavy Menstrual Bleeding (HMB) · Alnylam Pharmaceuticals
NCT06393712 · n=210 · Cerebral Amyloid Angiopathy · Alnylam Pharmaceuticals
NCT06845202 · n=105 · Obese or Overweight Healthy Volunteers; Type 2 Diabetes Mellitus (T2DM) · Alnylam Pharmaceuticals
NCT07223203 · n=125 · Hereditary Transthyretin-Mediated Amyloidosis With Polyneuropathy; hATTR-PN · Alnylam Pharmaceuticals
NCT06679946 · n=700 · Transthyretin Amyloidosis (ATTR) With Cardiomyopathy · Alnylam Pharmaceuticals
NCT07052903 · n=1750 · Transthyretin Amyloidosis With Cardiomyopathy · Alnylam Pharmaceuticals
NCT07181109 · n=11000 · High Risk Cardiovascular Disease; Hypertension; High Cardiovascular Risk · Alnylam Pharmaceuticals w/ Hoffmann-La Roche
QUREuniQure · AAV~59dP2 · 2026-11-301 in windowLEAPS ✓ to 2029-01-19
NCT06063850 · n=12 · Mesial Temporal Lobe Epilepsy · UniQure Biopharma B.V.
“2027 ATTR timeline as soft. uniQure got FDA alignment in June 2026 for an” open →
RNACCartesian Therapeutics · Cell~60dP2 · 2026-12-012 in windowoptions to 2027-05-21 · no LEAPS
NCT06038474 · n=6 · Systemic Lupus Erythematosus (SLE) · Cartesian Therapeutics
NCT06799247 · n=128 · Myasthaenia Gravis · Cartesian Therapeutics
“Therapeutics (RNAC)** — mRNA CAR-T for myasthenia gravis, pivotal window” open →
BEAMBeam Therapeutics · Editing~74dP2 · 2026-121 in windowLEAPS ✓ to 2028-01-21
NCT05885464 · n=5 · Lymphoblastic Lymphoma; T-Cell Lymphoblastic Leukemia/Lymphoma; Lymphoblastic Leukemia · Beam Therapeutics Inc.
LXEOLexeo Therapeutics · AAV~74dP2 · 2026-121 in windowoptions to 2027-05-21 · no LEAPS
NCT06109181 · n=10 · Arrhythmogenic Cardiomyopathy; PKP2-ACM; PKP2-ARVC · Lexeo Therapeutics
NTLAIntellia Therapeutics · Editing~74dFiling · 2026-12-151 in window · 1 beyondLEAPS ✓ to 2029-01-19
NCT06672237 · n=60 · Neuromuscular Disease; Neuromuscular Diseases (NMD); Neurodegenerative Disease · Intellia Therapeutics w/ Regeneron Pharmaceuticals
NCT06128629 · n=1200 · Transthyretin Amyloidosis (ATTR) With Cardiomyopathy · Intellia Therapeutics w/ Regeneron Pharmaceuticals
“(ATTR) trials earlier in 2026 — the registry may lag on this; treat NTLA's” open →
NTRANatera · Dx~74dP3 · 2026-121 in window · 1 beyondLEAPS ✓ to 2029-01-19
NCT05482516 · n=20 · Colon Adenocarcinoma; Rectal Adenocarcinoma; Gastric Adenocarcinoma · Georgetown University w/ Genentech, Inc.; Natera, Inc.
NCT05174169 · n=1912 · Stage III Colon Cancer · NRG Oncology w/ Natera, Inc.; National Cancer Institute (NCI)
IOVAIovance Biotherapeutics · Cell~91dP2 · 2027-01-013 in window · 1 beyondLEAPS ✓ to 2029-01-19
NCT05686226 · n=20 · Cervical Cancer; Throat Cancer; Oropharynx Cancer · Christian Hinrichs w/ National Cancer Institute (NCI); Iovance Biotherapeutics, Inc.
NCT03449108 · n=30 · Bone Sarcoma; Dedifferentiated Chondrosarcoma; Giant Cell Tumor of Bone · M.D. Anderson Cancer Center w/ Iovance Biotherapeutics, Inc.; National Cancer Institute (NCI)
NCT05361174 · n=53 · Unresectable Melanoma; Metastatic Melanoma; Stage III Non-small Cell Lung Cancer · Iovance Biotherapeutics, Inc.
NCT05727904 · n=670 · Metastatic Melanoma; Unresectable Melanoma; Melanoma · Iovance Biotherapeutics, Inc.
TSHATaysha Gene Therapies · AAV~161dP2 · 2027-03-121 in window · 2 beyondoptions to 2027-04-16 · no LEAPS
NCT04798235 · n=3 · Infantile GM2 Gangliosidosis (Disorder) · Dr. Anupam Sehgal w/ Taysha Gene Therapies, Inc.; GlycoNet
NCT07480564 · n=4 · Rett Syndrome · Taysha Gene Therapies, Inc.
NCT05606614 · n=17 · Rett Syndrome · Taysha Gene Therapies, Inc.
STOKStoke Therapeutics · RNA~164dP3 · 2027-031 in windowLEAPS ✓ to 2027-12-17
NCT06872125 · n=170 · Dravet Syndrome · Stoke Therapeutics, Inc
CRSPCRISPR Therapeutics · Editing~247dP3 · 2027-06-061 in window · 1 beyondLEAPS ✓ to 2029-01-19
NCT05329649 · n=13 · Sickle Cell Disease; Hydroxyurea Failure; Hydroxyurea Intolerance · Vertex Pharmaceuticals Incorporated w/ CRISPR Therapeutics
NCT05356195 · n=16 · Beta-Thalassemia; Thalassemia; Genetic Diseases, Inborn · Vertex Pharmaceuticals Incorporated w/ CRISPR Therapeutics
ARCTArcturus Therapeutics · mRNA~256dP2 · 2027-061 in windowoptions to 2027-03-19 · no LEAPS
NCT06747858 · n=33 · Cystic Fibrosis; CFTR Gene Mutation · Arcturus Therapeutics, Inc.
GHGuardant Health · Dxevent-driven · beyond window1 beyondLEAPS ✓ to 2029-01-19
NCT07004413 · n=267 · Colorectal Cancer Metastatic · Charite University, Berlin, Germany w/ Guardant Health, Inc.; Merck KGaA, Darmstadt, Germany
WGSGeneDx · Dxevent-driven · beyond window1 beyondLEAPS ✓ to 2029-01-19
NCT06472245 · n=363 · Patients With Non-Small Cell Lung Cancer · OSE Immunotherapeutics w/ Exystat; GeneDx
CRBUCaribou Biosciences · Editingnothing in window—options to 2027-04-16 · no LEAPS
No trials in the window and no known events — the jump risk here is early data, deals, or (for diagnostics) coverage decisions the registry cannot see.
EDITEditas Medicine · Editingnothing in window—LEAPS ✓ to 2028-01-21
No trials in the window and no known events — the jump risk here is early data, deals, or (for diagnostics) coverage decisions the registry cannot see.
ILMNIllumina · Dxcoverage & earnings driven1 routineLEAPS ✓ to 2028-01-21
1 routine trials (strain updates, extensions, tracers)
NCT04724369 · n=43 · Neuroblastoma · Innervate Radiopharmaceuticals LLC (Formerly: Illumina Radiopharmaceuticals LLC) w/ New Approaches to Neuroblastoma Therapy Consortium; Memorial Sloan Kettering Cancer Center
No trials in the window and no known events — the jump risk here is early data, deals, or (for diagnostics) coverage decisions the registry cannot see.
MYGNMyriad Genetics · Dxcoverage & earnings driven—options to 2027-05-21 · no LEAPS
No trials in the window and no known events — the jump risk here is early data, deals, or (for diagnostics) coverage decisions the registry cannot see.
PRMEPrime Medicine · Editingnothing in window—LEAPS ✓ to 2029-01-19
No trials in the window and no known events — the jump risk here is early data, deals, or (for diagnostics) coverage decisions the registry cannot see.
RCKTRocket Pharmaceuticals · AAVnothing in window—options to 2027-04-16 · no LEAPS
No trials in the window and no known events — the jump risk here is early data, deals, or (for diagnostics) coverage decisions the registry cannot see.
TEMTempus · Dxcoverage & earnings driven—LEAPS ✓ to 2029-01-19
No trials in the window and no known events — the jump risk here is early data, deals, or (for diagnostics) coverage decisions the registry cannot see.
WVEWave Life Sciences · RNAnothing in window—LEAPS ✓ to 2028-01-21
No trials in the window and no known events — the jump risk here is early data, deals, or (for diagnostics) coverage decisions the registry cannot see.
Topline data typically lands one to four months after primary completion — "data due" rows are the hottest zone.
NCT04768972 · n=89 · Amyotrophic Lateral Sclerosis · Ionis Pharmaceuticals, Inc. · LEAPS ✓
NCT06411288 · n=159 · DM1; Myotonic Dystrophy; Myotonic Dystrophy 1 · Avidity Biosciences, Inc. · LEAPS ✓
NCT06067230 · n=1153 · Respiratory Syncytial Virus · ModernaTX, Inc. · LEAPS ✓
NCT06018337 · n=541 · Metastatic Breast Cancer · DualityBio Inc. w/ BioNTech SE · LEAPS ✓
NCT05693142 · n=65 · Duchenne Muscular Dystrophy · REGENXBIO Inc.
manual entry · 2026-09-30 · guided
NCT05164094 · n=867 · Epstein-Barr Virus Infection · ModernaTX, Inc. · LEAPS ✓
NCT05407636 · n=735 · AMD; nAMD; Wet Age-related Macular Degeneration · AbbVie w/ REGENXBIO Inc.
NCT03368742 · n=12 · Duchenne Muscular Dystrophy · Solid Biosciences Inc.
NCT05918133 · n=42 · TNBC · Biotheus Inc. · LEAPS ✓
NCT03992430 · n=160 · Muscular Dystrophy, Duchenne · Sarepta Therapeutics, Inc. · LEAPS ✓
NCT04486378 · n=327 · Colorectal Cancer Stage II; Colorectal Cancer Stage III · BioNTech SE w/ Genentech, Inc. · LEAPS ✓
manual entry · 2026-11-15 · guided
NCT05095727 · n=15 · Glycogen Storage Disease · ModernaTX, Inc. · LEAPS ✓
NCT06063850 · n=12 · Mesial Temporal Lobe Epilepsy · UniQure Biopharma B.V. · LEAPS ✓
NCT06038474 · n=6 · Systemic Lupus Erythematosus (SLE) · Cartesian Therapeutics
NCT05392114 · n=154 · Hereditary Angioedema · Ionis Pharmaceuticals, Inc. · LEAPS ✓
NCT04704921 · n=671 · AMD; nAMD; Wet Age-related Macular Degeneration · AbbVie w/ REGENXBIO Inc.
NCT05482516 · n=20 · Colon Adenocarcinoma; Rectal Adenocarcinoma; Gastric Adenocarcinoma · Georgetown University w/ Genentech, Inc.; Natera, Inc. · LEAPS ✓
NCT05885464 · n=5 · Lymphoblastic Lymphoma; T-Cell Lymphoblastic Leukemia/Lymphoma; Lymphoblastic Leukemia · Beam Therapeutics Inc. · LEAPS ✓
NCT06109181 · n=10 · Arrhythmogenic Cardiomyopathy; PKP2-ACM; PKP2-ARVC · Lexeo Therapeutics
manual entry · 2026-12-15 · guided
NCT06799247 · n=128 · Myasthaenia Gravis · Cartesian Therapeutics
NCT06138743 · n=78 · Myotonic Dystrophy 1 · Sarepta Therapeutics, Inc. · LEAPS ✓
NCT05879055 · n=31 · Neuroendocrine Neoplasm · Biotheus Inc. · LEAPS ✓
NCT05686226 · n=20 · Cervical Cancer; Throat Cancer; Oropharynx Cancer · Christian Hinrichs w/ National Cancer Institute (NCI); Iovance Biotherapeutics, Inc. · LEAPS ✓
NCT06616532 · n=404 · SCLC · Biotheus Inc. · LEAPS ✓
NCT07496450 · n=4050 · Influenza · ModernaTX, Inc. · LEAPS ✓
NCT06592794 · n=37864 · Acute Gastroenteritis; Norovirus Acute Gastroenteritis · ModernaTX, Inc. · LEAPS ✓
NCT05683457 · n=84 · Cytomegalovirus Infection · ModernaTX, Inc. · LEAPS ✓
NCT04798235 · n=3 · Infantile GM2 Gangliosidosis (Disorder) · Dr. Anupam Sehgal w/ Taysha Gene Therapies, Inc.; GlycoNet
NCT05681351 · n=885 · Severe Hypertriglyceridemia · Ionis Pharmaceuticals, Inc. · LEAPS ✓
NCT06872125 · n=170 · Dravet Syndrome · Stoke Therapeutics, Inc · LEAPS ✓
NCT06153966 · n=85 · Prion Disease · Ionis Pharmaceuticals, Inc. · LEAPS ✓
NCT06305767 · n=230 · Bladder Cancer · Merck Sharp & Dohme LLC w/ ModernaTX, Inc. · LEAPS ✓
NCT07463846 · n=156 · Obesity · Alnylam Pharmaceuticals · LEAPS ✓
NCT06244082 · n=39 · DMD; Duchenne Muscular Dystrophy; Duchenne · Avidity Biosciences, Inc. · LEAPS ✓
NCT03449108 · n=30 · Bone Sarcoma; Dedifferentiated Chondrosarcoma; Giant Cell Tumor of Bone · M.D. Anderson Cancer Center w/ Iovance Biotherapeutics, Inc.; National Cancer Institute (NCI) · LEAPS ✓
NCT06138639 · n=60 · Duchenne Muscular Dystrophy · Solid Biosciences Inc.
NCT07133750 · n=100 · CRC (Colorectal Cancer) · Biotheus Inc. w/ BioNTech SE · LEAPS ✓
NCT07465224 · n=24 · Type 2 Diabetes Mellitus (T2DM) · Alnylam Pharmaceuticals · LEAPS ✓
NCT05881408 · n=148 · Duchenne Muscular Dystrophy · Sarepta Therapeutics, Inc. w/ Hoffmann-La Roche · LEAPS ✓
NCT05329649 · n=13 · Sickle Cell Disease; Hydroxyurea Failure; Hydroxyurea Intolerance · Vertex Pharmaceuticals Incorporated w/ CRISPR Therapeutics · LEAPS ✓
NCT05185843 · n=24 · Familial Chylomicronemia Syndrome · Ionis Pharmaceuticals, Inc. · LEAPS ✓
NCT07379580 · n=310 · Mpox (Monkeypox); Smallpox; Orthopoxvirus Infection · BioNTech SE w/ Coalition for Epidemic Preparedness Innovations · LEAPS ✓
NCT06449209 · n=110 · Extensive-stage Small-cell Lung Cancer; Small-cell Lung Cancer · BioNTech SE · LEAPS ✓
NCT06747858 · n=33 · Cystic Fibrosis; CFTR Gene Mutation · Arcturus Therapeutics, Inc.
NCT07575308 · n=24 · Von Willebrand Disease (VWD); Heavy Menstrual Bleeding (HMB) · Alnylam Pharmaceuticals · LEAPS ✓
NCT06672237 · n=60 · Neuromuscular Disease; Neuromuscular Diseases (NMD); Neurodegenerative Disease · Intellia Therapeutics w/ Regeneron Pharmaceuticals · LEAPS ✓
NCT06419621 · n=392 · Triple Negative Breast Cancer(TNBC) · Biotheus Inc. · LEAPS ✓
NCT06393712 · n=210 · Cerebral Amyloid Angiopathy · Alnylam Pharmaceuticals · LEAPS ✓
NCT05438329 · n=1123 · Advanced Solid Tumor · DualityBio Inc. w/ BioNTech SE · LEAPS ✓
NCT06914609 · n=156 · Angelman Syndrome · Ionis Pharmaceuticals, Inc. · LEAPS ✓
NCT05150691 · n=796 · HER2-positive Advanced Solid Tumor · DualityBio Inc. w/ BioNTech SE · LEAPS ✓
NCT05671510 · n=630 · Non Small Cell Lung Cancer · OncoC4, Inc. w/ BioNTech SE · LEAPS ✓
NCT04159103 · n=77 · Propionic Acidemia · ModernaTX, Inc. · LEAPS ✓
NCT06845202 · n=105 · Obese or Overweight Healthy Volunteers; Type 2 Diabetes Mellitus (T2DM) · Alnylam Pharmaceuticals · LEAPS ✓
NCT07604974 · n=72 · Hypertriglyceridemia; Severe Hypertriglyceridemia · Ionis Pharmaceuticals, Inc. · LEAPS ✓
NCT06430385 · n=48 · Methyl CpG Binding Protein 2 (MECP2) Duplication Syndrome · Ionis Pharmaceuticals, Inc. · LEAPS ✓
NCT05361174 · n=53 · Unresectable Melanoma; Metastatic Melanoma; Stage III Non-small Cell Lung Cancer · Iovance Biotherapeutics, Inc. · LEAPS ✓
5 routine trials hidden — strain updates, extensions, tracers
NCT05543616 · n=4338 · SARS-CoV-2 Virus; Severe Acute Respiratory Syndrome Coronavirus 2; COVID-19 · BioNTech SE w/ Pfizer · LEAPS ✓
NCT07222384 · n=344 · COVID-19; SARS-COV-2 Infection · BioNTech SE w/ Pfizer · LEAPS ✓
NCT04724369 · n=43 · Neuroblastoma · Innervate Radiopharmaceuticals LLC (Formerly: Illumina Radiopharmaceuticals LLC) w/ New Approaches to Neuroblastoma Therapy Consortium; Memorial Sloan Kettering Cancer Center · LEAPS ✓
NCT07300839 · n=5240 · COVID-19; SARS-COV-2 Infection · BioNTech SE w/ Pfizer · LEAPS ✓
NCT07798648 · n=700 · COVID-19 Vaccines · BioNTech SE w/ Pfizer · LEAPS ✓
34 Phase 3 trials beyond the window — registry dates are unreliable for event-driven trials (MRNA’s INTerpath-001 carried a 2029 date and read out 2026-08-19)
NCT05356195 · n=16 · Beta-Thalassemia; Thalassemia; Genetic Diseases, Inborn · Vertex Pharmaceuticals Incorporated w/ CRISPR Therapeutics · LEAPS ✓
NCT06128629 · n=1200 · Transthyretin Amyloidosis (ATTR) With Cardiomyopathy · Intellia Therapeutics w/ Regeneron Pharmaceuticals · LEAPS ✓
NCT06472245 · n=363 · Patients With Non-Small Cell Lung Cancer · OSE Immunotherapeutics w/ Exystat; GeneDx · LEAPS ✓
NCT07223203 · n=125 · Hereditary Transthyretin-Mediated Amyloidosis With Polyneuropathy; hATTR-PN · Alnylam Pharmaceuticals · LEAPS ✓
NCT05130450 · n=60 · Familial Chylomicronemia Syndrome · Ionis Pharmaceuticals, Inc. · LEAPS ✓
NCT06340568 · n=480 · Endometrial Cancer · BioNTech SE w/ DualityBio Inc.; BioNTech (Shanghai) Pharmaceuticals Co., Ltd. · LEAPS ✓
NCT05727904 · n=670 · Metastatic Melanoma; Unresectable Melanoma; Melanoma · Iovance Biotherapeutics, Inc. · LEAPS ✓
NCT06679946 · n=700 · Transthyretin Amyloidosis (ATTR) With Cardiomyopathy · Alnylam Pharmaceuticals · LEAPS ✓
NCT07236606 · n=2 · MPS II; Hunter Syndrome (MPS II) · REGENXBIO Inc.
NCT07782827 · n=30 · Angelman Syndrome · Ionis Pharmaceuticals, Inc. · LEAPS ✓
NCT07038200 · n=200 · Facioscapulohumeral Muscular Dystrophy; FSHD; FSHD - Facioscapulohumeral Muscular Dystrophy · Avidity Biosciences, Inc. · LEAPS ✓
NCT04534205 · n=358 · Unresectable Head and Neck Squamous Cell Carcinoma; Metastatic Head and Neck Cancer; Recurrent Head and Neck Cancer · BioNTech SE · LEAPS ✓
NCT07004413 · n=267 · Colorectal Cancer Metastatic · Charite University, Berlin, Germany w/ Guardant Health, Inc.; Merck KGaA, Darmstadt, Germany · LEAPS ✓
NCT06712355 · n=621 · Extensive-stage Small-cell Lung Cancer · BioNTech SE w/ Bristol-Myers Squibb · LEAPS ✓
NCT06712316 · n=1580 · Non-small Cell Lung Cancer · BioNTech SE w/ Bristol-Myers Squibb · LEAPS ✓
NCT07160634 · n=80 · Duchenne Muscular Dystrophy · Solid Biosciences Inc.
NCT05174169 · n=1912 · Stage III Colon Cancer · NRG Oncology w/ Natera, Inc.; National Cancer Institute (NCI) · LEAPS ✓
NCT07587242 · n=70 · Muscular Dystrophies; Muscular Dystrophies (Duchenne, Becker, Myotonic Dystrophy); Muscular Disorders, Atrophic · Avidity Biosciences, Inc. · LEAPS ✓
NCT07298447 · n=20 · Hereditary Angioedema (HAE) · Ionis Pharmaceuticals, Inc. · LEAPS ✓
NCT05667493 · n=1400 · Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM) · Ionis Pharmaceuticals, Inc. w/ AstraZeneca · LEAPS ✓
NCT05071300 · n=151 · Hereditary Transthyretin-Mediated Amyloid Polyneuropathy · Ionis Pharmaceuticals, Inc. · LEAPS ✓
NCT05933577 · n=1089 · Melanoma · Merck Sharp & Dohme LLC w/ ModernaTX, Inc. · LEAPS ✓
NCT07173751 · n=558 · Breast Neoplasms · BioNTech SE w/ Bristol-Myers Squibb · LEAPS ✓
NCT07221357 · n=990 · Untreated, Unresectable, or Metastatic Colorectal Cancer · Bristol-Myers Squibb w/ BioNTech SE · LEAPS ✓
NCT07052903 · n=1750 · Transthyretin Amyloidosis With Cardiomyopathy · Alnylam Pharmaceuticals · LEAPS ✓
NCT06077760 · n=868 · Non-small Cell Lung Cancer · Merck Sharp & Dohme LLC w/ ModernaTX, Inc. · LEAPS ✓
NCT07727538 · n=12 · Familial Chylomicronemia Syndrome · Ionis Pharmaceuticals, Inc. · LEAPS ✓
NCT07361497 · n=850 · Non-small Cell Lung Cancer (NSCLC) · Bristol-Myers Squibb w/ BioNTech SE · LEAPS ✓
NCT07181109 · n=11000 · High Risk Cardiovascular Disease; Hypertension; High Cardiovascular Risk · Alnylam Pharmaceuticals w/ Hoffmann-La Roche · LEAPS ✓
NCT07008469 · n=199 · Myotonic Dystrophy Type 1; DM1; Myotonic Dystrophy · Avidity Biosciences, Inc. · LEAPS ✓
NCT07221149 · n=690 · Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma · Bristol-Myers Squibb w/ BioNTech SE · LEAPS ✓
NCT07365995 · n=736 · Metastatic Castration-resistant Prostate Cancer · BioNTech SE w/ BioNTech (Shanghai) Pharmaceuticals Co., Ltd.; DualityBio Inc. · LEAPS ✓
NCT07480564 · n=4 · Rett Syndrome · Taysha Gene Therapies, Inc.
NCT05606614 · n=17 · Rett Syndrome · Taysha Gene Therapies, Inc.
A candidate is a sponsor or collaborator on an industry Phase 3 that maps to a US-listed ticker and is neither on the watchlist nor big pharma. Say the word to add one (or mark it in universe.yaml dispositions).
Full sponsor table (60 names — majors, watchlist and unmapped greyed)
2026-08-20 — UI v1 rejected; redesign spec written
Owner's verdict on the v1 dashboard: a complete shit show — can't keep track of or find anything. Fair. v1 renders all 94 trials as one stack of dense tables with no triage, no per-name view, no search, and the journal buried at the bottom.
- Full redesign spec written at
stockradar/design/ui-spec.md: five views (Today / Names / Calendar / Candidates / More), global search, group filter chips, a rolling 14-day activity feed, routine-trial noise hiding, ticker cards with a per-name detail panel, bottom tab bar on phone, strict color discipline. Vanilla JS now allowed; still one static file, no framework. - The spec went to Claude Design for a visual draft; implementation in
render.pyfollows once the design is settled. - The main Signal Radar dashboard sidebar now links to Catalysts (
signal_radar/preview.py,_NAV_MAIN).
2026-08-19 — Radar built and deployed
Goal set: find and be positioned for genomics innovation over the next 3–5 years. The radar exists so that nothing discussed in a Claude session gets lost: findings land here in the journal, candidates land in the candidates section with a first-seen date, and the calendar tracks every known catalyst.
What went live today
- The Phase 3 screener was validated live against ClinicalTrials.gov (its query syntax works as written) and deployed unchanged, wrapped by
radar_run.py. Nightly run at 05:30 ET weekdays; discovery sweep plus candidate mapping on Sundays. - The wrapper adds what the raw screener lacked: a Phase 2 pass for the therapeutic names (the biggest platform jumps come from early data, not Phase 3), estimated-versus-actual completion-date tracking (a flip to "actual" means last patient visit done, topline typically inside one to four months), sponsor-and-collaborator ticker mapping through SEC EDGAR so discovery surfaces tradeable names instead of raw sponsor strings, and MarketData-based LEAPS availability per name for long-horizon positioning.
- Data providers confirmed: marketdata.app is primary (token already lives on this box and the account is IP-locked here, which is correct) and Databento is the backup when MarketData credits run out. The IV term-structure scan around catalysts is built but off by default to protect the MarketData credit ceiling — flip
iv_scan: trueinuniverse.yamlto enable.
First findings (from the live runs)
- The 12-month Phase 3 window holds 17 trials across only 9 of 30 watchlist names. Nearest: REGENXBIO's Duchenne gene therapy (September 2026), the AbbVie-run RGX-314 eye trials (October and December 2026), Sarepta's high-dose eteplirsen (end of October 2026).
- The discovery sweep surfaced two apparently-new names; the tradeability check then killed one of them, which is the system working: **Cartesian Therapeutics (RNAC)** — mRNA CAR-T for myasthenia gravis, pivotal window November 2026, options listed but only out to February 2027 — was added to the watchlist. Adverum looked like a find, but SEC EDGAR and MarketData both came back empty, and it turned out Eli Lilly acquired Adverum ($3.56/share plus CVR, delisted 2025-12-09) — before the pivotal readout, which is the M&A-before-data pattern to expect more of in gene therapy.
- Same check exposed a stale name in the original watchlist: Abbott completed its $21B takeover of Exact Sciences on 2026-03-23, so EXAS is delisted too. Both now live in the
delistedlist in universe.yaml. - Regulatory picture (from today's search, sources in events.yaml): Intellia's HAELO pivotal for hereditary angioedema succeeded in April 2026; BLA guided for H2 2026, launch planned H1 2027 — would be the first in-vivo CRISPR approval. Note the FDA also placed a hold on two Intellia nex-z (ATTR) trials earlier in 2026 — the registry may lag on this; treat NTLA's 2027 ATTR timeline as soft. uniQure got FDA alignment in June 2026 for an accelerated-approval BLA on AMT-130 (Huntington's), submission guided Q3 2026. Alnylam/Regeneron's cemdisiran has a November 2026 FDA action date.
Post-mortem, same evening: would this have flagged today's MRNA double?
Honest answer: no, not as built this morning — and the reason reshaped the radar. Moderna roughly doubled today on INTerpath-001: the Merck-partnered individualized mRNA cancer vaccine plus Keytruda met its endpoints in resected melanoma — the first positive Phase 3 for any mRNA cancer therapy (FDA also cleared the mFLUSIVA flu shot the same day). The trial WAS reachable by our sponsor query (ModernaTX is listed as collaborator under Merck's lead on NCT05933577), but its registry primary-completion date is October 2029 — today's result came from an event-driven interim analysis, three years ahead of the registry date, so a forward completion-date window could never contain it. Meanwhile the readout was guided by the companies for 2026, meaning the guidance layer (events.yaml) was the right net and simply hadn't been fed.
Three changes went in tonight:
- Beyond-window pass: every watchlist name's Phase 3 trials out to five years now render in their own section, so standing heavyweights like INTerpath-001 are visible even when the registry date is far and unreliable.
- Lookback window: trials whose primary completion passed in the last ~4 months (including newly COMPLETED ones) now stay on the calendar marked "data due" — completion-to-topline is the hottest zone and the old filter structurally dropped it.
- Standing chore, not yet automated: once a quarter (earnings season), sweep each watchlist name's guidance for "data expected in ..." statements into events.yaml. The registry times the ordinary readouts; only guidance times the big event-driven ones.
Also from tonight: a daily email brief now goes out after each run — changes, data-due list, everything inside 30 days, new candidates — via the same Resend account the Signal Radar digest uses.
Decisions
- Frontend is a static page at radar.gpt.cafe/catalysts/ — no framework, no build chain, so it will still render in five years.
- Diagnostics names stay on the radar but their real catalysts are coverage and guideline decisions, not trials; don't read their empty trial rows as "no catalysts".
- MarketData enrichment kept deliberately cheap (expirations only, cached a day). The screener file itself stays untouched per the deployment brief.
Gene editing
The first wave of one-time in-vivo editing treatments is crossing from trials into approvals between now and 2028. Intellia's hereditary angioedema program read out positive in April 2026 and is heading for the first in-vivo CRISPR approval; base and prime editing sit a few years behind with their first clinical proof points. These names move violently on early human data, not just Phase 3.
mRNA & individualized therapy
Beyond vaccines, the bet is individualized treatment — cancer vaccines tailored per patient and mRNA used as a drug. Partnered programs often run under the pharma partner's name (Merck runs the key Moderna oncology trials), so the discovery sweep is the backstop here.
RNA silencing & antisense
The most de-risked platform in the group: Alnylam and Ionis already sell approved drugs and fund broad pipelines from revenue. The 3–5 year story is expansion from rare disease into large populations (cardio, metabolic, neuro), where a single win re-rates the platform.
Gene therapy (AAV)
Highest torque and highest risk: single-asset companies where one readout or FDA meeting can halve or double the stock. uniQure's Huntington's program reaching the FDA under accelerated approval is the bellwether for the whole class; Sarepta is the cautionary tale on regulatory whiplash. Big pharma is already shopping here — Lilly took Adverum out in late 2025 before its pivotal even read out.
Cell therapy
Engineered-cell treatments moving from blood cancers into solid tumors and autoimmune disease. Manufacturing economics decide the winners as much as the science does.
Diagnostics & sequencing
These names rarely jump on trial readouts — their catalysts are Medicare coverage decisions, guideline inclusions, and earnings. The trial radar keeps them for coverage, but watch reimbursement news, not Phase 3 dates. Consolidation is live here too — Abbott closed its $21B Exact Sciences takeover in March 2026.
Data: ClinicalTrials.gov v2, SEC EDGAR, marketdata.app (Databento backup). Raw: latest.csv · latest.json. Sources in ~/optionsradar/stockradar/; nightly 05:30 ET weekdays, discovery Sundays; add tickers in universe.yaml, FDA dates in events.yaml, notes in journal/ — or ask Claude.